AimTo investigate the bidirectional influence between periodontitis and psoriasis, using the respective experimental models of ligature‐ and imiquimod‐induced diseases on murine models.Materials and MethodsThirty‐two C57/BL6J mice were randomly allocated to four experimental groups: control (P− Pso−), ligature‐induced periodontitis (P+ Pso−), imiquimod‐induced psoriasis (P− Pso+) and periodontitis and psoriasis (P+ Pso+). Samples (maxilla, dorsal skin and blood) were harvested immediately after death. Measures of periodontitis (distance between the cemento‐enamel junction and alveolar bone crest [CEJ–ABC] and the number of osteoclasts) and psoriasis (epidermal thickness and infiltrate cell [/0.03mm2]) severity as well as systemic inflammation (IL‐6, IL‐17A, TNF‐α) were collected.ResultsThe P+ Pso+ group exhibited the most severe experimental periodontitis and psoriasis, with the highest values of CEJ–ABC, number of osteoclasts, epidermal thickness and infiltrate cells in the dorsal skin, as well as the highest blood cytokine concentration. The P+ Pso− group presented with higher cell infiltrate (/0.03mm2) compared to the control group (p <.05), while the P− Pso+ group showed substantially higher alveolar bone loss (CEJ–ABC) than the control group (p <.05).ConclusionsExperimental periodontitis may initiate and maintain psoriasiform skin inflammation and, vice versa, experimental psoriasis may contribute to the onset of periodontitis. In a combined model of the diseases, we propose a bidirectional association between periodontitis and psoriasis via systemic inflammation.

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牙周炎和银屑病有关联吗？临床前小鼠模型


目的 在小鼠模型上使用结扎和咪喹莫特诱导的疾病的相应实验模型，研究牙周炎和银屑病之间的双向影响。材料和方法将 32 只 C57/BL6J 小鼠随机分为 4 个实验组：对照组 （P− Pso−）、结扎诱导的牙周炎 （P+ Pso−）、咪喹莫特诱导的银屑病 （P− Pso+） 以及牙周炎和银屑病 （P+ Pso+）。标本（上颌骨、背皮和血液）在死后立即采集。收集牙周炎 （牙骨质-牙釉质交界处和牙槽骨嵴之间的距离 [CEJ-ABC] 和破骨细胞的数量）和银屑病 （表皮厚度和浸润细胞 [/0.03mm2]）严重程度以及全身炎症 （IL-6、IL-17A、TNF-α） 的测量值。结果P+ Pso+ 组表现为最严重的实验性牙周炎和银屑病，其中 CEJ-ABC 值最高，破骨细胞数量最高，背侧皮肤表皮厚度和浸润细胞最高，血细胞因子浓度最高。与对照组 （p <.05） 相比，P+ Pso-组表现出更高的细胞浸润率 （/0.03mm2），而 P-Pso+ 组表现出比对照组 （p <.05） 高得多的肺泡骨丢失 （CEJ-ABC）。结论实验性牙周炎可能引发并维持银屑病样皮肤炎症，反之亦然，实验性银屑病可能导致牙周炎的发作。在疾病的组合模型中，我们提出牙周炎和银屑病之间通过全身炎症之间存在双向关联。