Small heat shock proteins (sHSPs) play key roles in cellular stress and several human diseases. The direct effects of some post-translational modifications (PTMs) on certain sHSPs have been characterized, raising the possibility that small molecules could be used to modulate these modifications and indirectly up- or downregulate sHSP activity.

中文翻译：

---

针对小热休克蛋白修饰的潜力

小热休克蛋白 (sHSP) 在细胞应激和多种人类疾病中发挥着关键作用。一些翻译后修饰 (PTM) 对某些 sHSP 的直接影响已经得到表征，这提高了小分子可用于调节这些修饰并间接上调或下调 sHSP 活性的可能性。