HIF-1α and adaptor protein LIM and senescent cell antigen-like domains protein 1 axis promotes tubulointerstitial fibrosis by interacting with vimentin in angiotensin II-induced hypertension,British Journal of Pharmacology

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HIF-1α and adaptor protein LIM and senescent cell antigen-like domains protein 1 axis promotes tubulointerstitial fibrosis by interacting with vimentin in angiotensin II-induced hypertension
British Journal of Pharmacology ( IF 6.8 ) Pub Date : 2024-05-03 , DOI: 10.1111/bph.16358
Wei-Jie Ni ₁ , Zuo-Lin Li ₁ , Xian-Li Wen ₂ , Jia-Ling Ji ₃ , Hong Liu ₁ , Qing Yin ₁ , Liang-Yun-Zi Jiang ₁ , Yi-Lin Zhang ₁ , Yi Wen ₁ , Tao-Tao Tang ₁ , Wei Jiang ₁ , Lin-Li Lv ₁ , Wei-Hua Gan ₂ , Bi-Cheng Liu ₁ , Bin Wang ₁

Affiliation

Activation of the renin-angiotensin system, as a hallmark of hypertension and chronic kidney diseases (CKD) is the key pathophysiological factor contributing to the progression of tubulointerstitial fibrosis. LIM and senescent cell antigen-like domains protein 1 (LIMS1) plays an essential role in controlling of cell behaviour through the formation of complexes with other proteins. Here, the function and regulation of LIMS1 in angiotensin II (Ang II)-induced hypertension and tubulointerstitial fibrosis was investigated.

中文翻译：

HIF-1α和接头蛋白LIM以及衰老细胞抗原样结构域蛋白1轴通过与血管紧张素II诱导的高血压中的波形蛋白相互作用促进肾小管间质纤维化

肾素-血管紧张素系统的激活是高血压和慢性肾脏病（CKD）的标志，是导致肾小管间质纤维化进展的关键病理生理因素。 LIM 和衰老细胞抗原样结构域蛋白 1 (LIMS1) 通过与其他蛋白形成复合物，在控制细胞行为方面发挥重要作用。在此，研究了 LIMS1 在血管紧张素 II (Ang II) 诱导的高血压和肾小管间质纤维化中的功能和调节。

更新日期：2024-05-03

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