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Molecular Pathways Governing the Termination of Liver Regeneration
Pharmacological Reviews ( IF 19.3 ) Pub Date : 2024-05-01 , DOI: 10.1124/pharmrev.123.000955 Lianne R de Haan 1 , Rowan F van Golen 1 , Michal Heger 2
Pharmacological Reviews ( IF 19.3 ) Pub Date : 2024-05-01 , DOI: 10.1124/pharmrev.123.000955 Lianne R de Haan 1 , Rowan F van Golen 1 , Michal Heger 2
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The liver has the unique capacity to regenerate, and up to 70% of the liver can be removed without detrimental consequences to the organism. Liver regeneration is a complex process involving multiple signaling networks and organs. Liver regeneration proceeds through three phases: the initiation phase, the growth phase, and the termination phase. Termination of liver regeneration occurs when the liver reaches a liver-to-body weight that is required for homeostasis, the so-called “hepatostat.” The initiation and growth phases have been the subject of many studies. The molecular pathways that govern the termination phase, however, remain to be fully elucidated. This review summarizes the pathways and molecules that signal the cessation of liver regrowth after partial hepatectomy and answers the question, “What factors drive the hepatostat?”
中文翻译：
控制肝脏再生终止的分子途径
肝脏具有独特的再生能力，高达 70% 的肝脏可以被切除，而不会对有机体产生有害后果。肝脏再生是一个复杂的过程，涉及多个信号网络和器官。肝脏再生经历三个阶段：起始阶段、生长期和终止阶段。当肝脏达到体内平衡所需的肝脏重量比（即所谓的“肝稳态”）时，肝脏再生就会终止。起始阶段和生长阶段一直是许多研究的主题。然而，控制终止阶段的分子途径仍有待充分阐明。这篇综述总结了部分肝切除术后肝脏再生停止的信号通路和分子，并回答了“哪些因素驱动肝脏抑制器？”的问题。
更新日期：2024-05-03
中文翻译：
控制肝脏再生终止的分子途径
肝脏具有独特的再生能力，高达 70% 的肝脏可以被切除，而不会对有机体产生有害后果。肝脏再生是一个复杂的过程，涉及多个信号网络和器官。肝脏再生经历三个阶段：起始阶段、生长期和终止阶段。当肝脏达到体内平衡所需的肝脏重量比（即所谓的“肝稳态”）时，肝脏再生就会终止。起始阶段和生长阶段一直是许多研究的主题。然而，控制终止阶段的分子途径仍有待充分阐明。这篇综述总结了部分肝切除术后肝脏再生停止的信号通路和分子，并回答了“哪些因素驱动肝脏抑制器？”的问题。
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