Using a human stem cell-based model to understand how the human epiblast forms at the very beginning of implantation, Indana et al.¹ establish a role for pushing forces that are generated by apical actin polymerization and reveal a two-stage, biomechanics-driven lumen growth process underlying epiblast cavity morphogenesis.

中文翻译：

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肌动蛋白推动打开渗漏的管腔

Indana 等人使用基于人类干细胞的模型来了解人类外胚层在植入初期是如何形成的。^{图 1}确定了顶端肌动蛋白聚合产生的推力的作用，并揭示了外胚层腔形态发生的两阶段、生物力学驱动的管腔生长过程。