Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and Aggarwal et al. show that persistent Sox9 activity in epithelial and endothelial cells activates fibroblasts creating fibrotic microdomains in multiple organs.

中文翻译：

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Sox9 协调的细胞邻域产生纤维化

再生能力差的器官会沉积疤痕组织来修复损伤。阿加瓦尔等人。确定短暂的 Sox9 活性对于早期近端小管上皮再生是必要的，而 Trogisch 等人。和阿加瓦尔等人。研究表明，上皮细胞和内皮细胞中持续存在的 Sox9 活性会激活成纤维细胞，在多个器官中产生纤维化微区。