A packed reactor bed incorporating a polymer-supported isothiourea HyperBTM catalyst derivative has been used to promote the enantioselective synthesis of a range of heterocyclic products derived from α-azol-2-ylacetophenones and -acetamides combined with alkyl, aryl, and heterocyclic α,β-unsaturated homoanhydrides in continuous flow via an α,β-unsaturated acyl-ammonium intermediate. The products are generated in good to excellent yields and generally in excellent enantiopurity (up to 97:3 er). Scale-up is demonstrated on a 15 mmol scale, giving the heterocyclic product in 68% overall yield with 98:2 er after recrystallization.

中文翻译：

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连续流中的对映选择性合成：聚合物支持的异硫脲催化的对映选择性迈克尔加成 - α-Azol-2-基苯乙酮环化

包含聚合物负载的异硫脲 HyperBTM 催化剂衍生物的填充反应器床已用于促进一系列杂环产物的对映选择性合成，这些杂环产物衍生自 α-唑-2-基苯乙酮和乙酰胺与烷基、芳基和杂环 α,β 的组合-通过α,β-不饱和酰基铵中间体连续流动的不饱和高酸酐。产品的产率良好至优异，并且通常具有优异的对映体纯度（高达 97:3 er）。在 15 mmol 规模上进行了放大，重结晶后杂环产物的总产率为 68%，摩尔比为 98:2。