npj Microgravity ( IF 4.4 ) Pub Date : 2024-05-01 , DOI: 10.1038/s41526-024-00395-3
Craig R G Willis 1 , Marco Calvaruso 2 , Debora Angeloni 3 , Sarah Baatout 4 , Alexandra Benchoua 5 , Juergen Bereiter-Hahn 6 , Daniele Bottai 7 , Judith-Irina Buchheim 8 , Eugénie Carnero-Diaz 9 , Sara Castiglioni 10 , Duccio Cavalieri 11 , Gabriele Ceccarelli 12 , Alexander Chouker 8 , Francesca Cialdai 13 , Gianni Ciofani 14 , Giuseppe Coppola 15 , Gabriella Cusella 12 , Andrea Degl'Innocenti 14, 16 , Jean-Francois Desaphy 17 , Jean-Pol Frippiat 18 , Michael Gelinsky 19 , Giada Genchi 14 , Maria Grano 17 , Daniela Grimm 20, 21 , Alain Guignandon 22 , Raúl Herranz 23 , Christine Hellweg 24 , Carlo Saverio Iorio 25 , Thodoris Karapantsios 26 , Jack van Loon 27 , Matteo Lulli 28 , Jeanette Maier 10 , Jos Malda 29 , Emina Mamaca 30 , Lucia Morbidelli 31 , Andreas Osterman 32 , Aleksandr Ovsianikov 33 , Francesco Pampaloni 34 , Elizabeth Pavezlorie 35 , Veronica Pereda-Campos 36 , Cyrille Przybyla 37 , Petra Rettberg 38 , Angela Maria Rizzo 39 , Kate Robson-Brown 40 , Leonardo Rossi 41 , Giorgio Russo 2 , Alessandra Salvetti 41 , Chiara Risaliti 13 , Daniela Santucci 42 , Matthias Sperl 43 , Kevin Tabury 4 , Sara Tavella 44 , Christiane Thielemann 45 , Ronnie Willaert 46 , Monica Monici 13 , Nathaniel J Szewczyk 47
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Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.
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如何获得不同生物系统中适应微重力所涉及的分子网络的综合图片?
欧洲航天局 (ESA) 会定期与科学界协商更新科学路线图。ESA SciSpacE 科学社区白皮书 (SSCWP) 9“空间和模拟环境中的生物学”侧重于 5 个主要主题领域,旨在解决社区确定的空间生物学中的关键知识差距。在这里,我们提出了一个已确定的主题领域,这也是太空生命科学研究的一个未解之谜:“如何获得不同生物系统中适应微重力所涉及的分子网络的综合图片?手稿报告了社区在上述主题领域中发现的主要知识差距,以及社区提出的解决尚未弥合的差距的方法。此外,还简要讨论了这些研究活动可能对太空探索计划以及在地球上工业和技术领域的应用具有相关性。