<br>海水养殖废水中抗生素和抗生素抗性基因（ARG）的系统评价：微藻-细菌共生系统（MBSS）去除抗生素，ARG在宏基因组上的表征,Science of the Total Environment

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海水养殖废水中抗生素和抗生素抗性基因（ARG）的系统评价：微藻-细菌共生系统（MBSS）去除抗生素，ARG在宏基因组上的表征
Science of the Total Environment ( IF 8.2 ) Pub Date : 2024-04-23 , DOI: 10.1016/j.scitotenv.2024.172601
Weijia Gong ₁ , Lin Guo ₂ , Chenxin Huang ₂ , Binghan Xie ₃ , Mengmeng Jiang ₂ , Yuzhou Zhao ₂ , Haotian Zhang ₂ , YuXuan Wu ₃ , Heng Liang ₄

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海水养殖废水中抗生素残留严重影响水生环境。抗生素应激下产生的抗生素抗性基因（ARG）通过环境流动，最终进入人体，严重影响人类健康。微藻-细菌共生系统（MBSS）可以去除海水养殖中的抗生素并减少ARG流入环境。本综述概括了海水养殖废水的现状、MBSS 对抗生素的去除机制以及宏基因组分析下的生物分子信息。当遇到抗生素时，MBSS 内的细胞外聚合物 (EPS) 含量显着增加，同时 EPS 内的蛋白质 (PN) 成分比例也随之升高，这限制了抗生素进入细胞内部。群体感应通过信号传导刺激微生物产生生物反应（DNA 合成 - 用于粘附）。氧化应激促进基因表达（偶联、缀合），从而增强 MBSS 中的水平基因转移 (HGT)。宏基因组检测的微生物群落以细菌-微藻系统中的需氧细菌为主。与需氧菌相比，厌氧菌具有减少ARGs分布的显着优势。总体而言，MBSS 在缓解海水养殖废水中抗生素和抗性基因带来的挑战方面表现出显着的功效。

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A systematic review of antibiotics and antibiotic resistance genes (ARGs) in mariculture wastewater: Antibiotics removal by microalgal-bacterial symbiotic system (MBSS), ARGs characterization on the metagenomic

Antibiotic residues in mariculture wastewater seriously affect the aquatic environment. Antibiotic Resistance Genes (ARGs) produced under antibiotic stress flow through the environment and eventually enter the human body, seriously affecting human health. Microalgal-bacterial symbiotic system (MBSS) can remove antibiotics from mariculture and reduce the flow of ARGs into the environment. This review encapsulates the present scenario of mariculture wastewater, the removal mechanism of MBSS for antibiotics, and the biomolecular information under metagenomic assay. When confronted with antibiotics, there was a notable augmentation in the extracellular polymeric substances (EPS) content within MBSS, along with a concurrent elevation in the proportion of protein (PN) constituents within the EPS, which limits the entry of antibiotics into the cellular interior. Quorum sensing stimulates the microorganisms to produce biological responses (DNA synthesis - for adhesion) through signaling. Oxidative stress promotes gene expression (coupling, conjugation) to enhance horizontal gene transfer (HGT) in MBSS. The microbial community under metagenomic detection is dominated by aerobic bacteria in the bacterial-microalgal system. Compared to aerobic bacteria, anaerobic bacteria had the significant advantage of decreasing the distribution of ARGs. Overall, MBSS exhibits remarkable efficacy in mitigating the challenges posed by antibiotics and resistant genes from mariculture wastewater.

更新日期：2024-04-23

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