Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases,Advanced Drug Delivery Reviews

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Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-21 , DOI: 10.1016/j.addr.2024.115323
Pengxuan Zhao ₁ , Tiantian Wu ₂ , Yu Tian ₃ , Jia You ₂ , Xinwu Cui ₄

Affiliation

With the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood–brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FUS) combined with contrast agents—microbubbles (MBs) to achieve transient and reversible BBB opening. This review provides a comprehensive exploration of the fundamental mechanisms behind FUS/MBs-mediated BBB opening and spotlights recent breakthroughs in its application for neurodegenerative diseases. Furthermore, it addresses the current challenges and presents future perspectives in this field.

中文翻译：

聚焦超声诱导血脑屏障开放在神经退行性疾病临床应用的最新进展

随着人口老龄化的加剧，神经退行性疾病已成为一个重要的健康问题。血脑屏障（BBB）在维持中枢神经系统的稳定性方面发挥着重要作用，但它对神经退行性疾病治疗的药物输送构成了巨大的障碍。人们设计了各种方法来应对这一挑战，但每种方法都有其自身的局限性。一种特别有前途的非侵入性方法涉及利用聚焦超声（FUS）与造影剂微泡（MB）相结合来实现瞬时和可逆的血脑屏障打开。这篇综述全面探讨了 FUS/MB 介导的 BBB 打开背后的基本机制，并重点介绍了其在神经退行性疾病应用中的最新突破。此外，它还解决了当前的挑战并提出了该领域的未来前景。

更新日期：2024-04-21

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