Fusobacterium nucleatum carcinogenesis and drug delivery interventions,Advanced Drug Delivery Reviews

当前位置： X-MOL 学术 › Adv. Drug Deliver. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fusobacterium nucleatum carcinogenesis and drug delivery interventions
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-21 , DOI: 10.1016/j.addr.2024.115319
Zhenzhen Chen ₁ , Leaf Huang ₁

Affiliation

The microbiome has emerged as a significant biomarker and modulator in cancer development and treatment response. Recent research highlights the notable role of () in various tumor types, including breast, colorectal, esophageal, gastric, pancreatic, and lung cancers. Accumulating evidence suggests that the local microbial community forms an integral component of the tumor microenvironment, with bacterial communities within tumors displaying specificity to tumor types. Mechanistic investigations indicate that tumor-associated microbiota can directly influence tumor initiation, progression, and responses to chemotherapy or immunotherapy. This article presents a comprehensive review of microbial communities especially in tumor tissue, exploring their roles and underlying mechanisms in tumor development, treatment, and prevention. When the tumor-associated is killed, the host immune response is activated to recognize tumor cells. Bacteria epitopes restricted by the host antigens, can be identified for future anti-bacteria/tumor vaccine development.

中文翻译：

具核梭杆菌致癌和药物输送干预

微生物组已成为癌症发展和治疗反应中的重要生物标志物和调节剂。最近的研究强调了 () 在各种肿瘤类型中的显着作用，包括乳腺癌、结直肠癌、食管癌、胃癌、胰腺癌和肺癌。越来越多的证据表明，局部微生物群落构成了肿瘤微环境的一个组成部分，肿瘤内的细菌群落对肿瘤类型表现出特异性。机制研究表明，肿瘤相关微生物群可以直接影响肿瘤的发生、进展以及对化疗或免疫治疗的反应。本文对微生物群落（尤其是肿瘤组织中的微生物群落）进行了全面综述，探讨了它们在肿瘤发生、治疗和预防中的作用和潜在机制。当肿瘤相关细胞被杀死时，宿主免疫反应就会被激活以识别肿瘤细胞。可以鉴定受宿主抗原限制的细菌表位，用于未来的抗细菌/肿瘤疫苗开发。

更新日期：2024-04-21

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南