Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications,Advanced Drug Delivery Reviews

当前位置： X-MOL 学术 › Adv. Drug Deliver. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-06 , DOI: 10.1016/j.addr.2024.115303
Jacob D Bonadio ₁ , Ghazal Bashiri ₁ , Patrick Halligan ₁ , Michael Kegel ₁ , Fatima Ahmed ₁ , Karin Wang ₁

Affiliation

Fibronectin (FN) is a critical component of the extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with other ECM proteins, growth factors, cells, and associated signaling pathways, thus influencing the progress of diseases such as fibrosis and autoimmune disorders. Therefore, developing therapeutics that directly target FN or its interaction with cells and other ECM components can be an intriguing approach to address autoimmune and fibrosis pathogenesis.

中文翻译：

自身免疫和纤维化应用中纤连蛋白治疗靶向的递送技术

纤连蛋白 (FN) 是细胞外基质 (ECM) 的重要组成部分，有助于各种生理过程，包括组织修复和免疫反应调节。 FN 调节多种细胞功能，如粘附、增殖、迁移、分化和细胞因子释放。 FN 表达、沉积和分子结构的改变可以深刻影响其与其他 ECM 蛋白、生长因子、细胞和相关信号通路的相互作用，从而影响纤维化和自身免疫性疾病等疾病的进展。因此，开发直接靶向 FN 或其与细胞和其他 ECM 成分相互作用的疗法可能是解决自身免疫和纤维化发病机制的一种有趣方法。

更新日期：2024-04-06

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南