Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series,JACC: Cardiovascular Imaging

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Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series
JACC: Cardiovascular Imaging ( IF 12.8 ) Pub Date : 2024-04-08 , DOI: 10.1016/j.jcmg.2024.03.001
Zahra Raisi-Estabragh ₁ , Liliana Szabo ₂ , Art Schuermans ₃ , Ahmed M Salih ₄ , Calvin W L Chin ₅ , Hajnalka Vágó ₆ , Andre Altmann ₇ , Fu Siong Ng ₈ , Pankaj Garg ₉ , Sofia Pavanello ₁₀ , Thomas H Marwick ₁₁ , Steffen E Petersen ₁₂

Affiliation

William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, United Kingdom; Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom.
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, United Kingdom; Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom; Semmelweis University, Heart and Vascular Center, Budapest, Hungary.
Faculty of Medicine, KU Leuven, Leuven, Belgium; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, United Kingdom; Department of Population Health Sciences, University of Leicester, Leicester UK; Department of Computer Science, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq.
Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore; Cardiovascular Academic Clinical Programme, Duke National University of Singapore Medical School, Singapore, Singapore.
Semmelweis University, Heart and Vascular Center, Budapest, Hungary.
Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
University of East Anglia, Norwich Medical School, Norwich, United Kingdom; Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom.
Occupational Medicine, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy; Padua Hospital, Occupational Medicine Unit, Padua, Italy; University Center for Space Studies and Activities "Giuseppe Colombo" - CISAS, University of Padua, Padua, Italy.
Baker Heart and Diabetes Institute, Melbourne, Australia.
William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, United Kingdom; Barts Heart Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom; Health Data Research UK, London, United Kingdom.

Population aging is one of the most important demographic transformations of our time. Increasing the “health span”—the proportion of life spent in good health—is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular disease is a major cause of ill health and premature death in older people. The rate at which biological aging occurs varies across individuals of the same age and is influenced by a wide range of genetic and environmental exposures. The authors review the hallmarks of biological cardiovascular aging and their capture using imaging and other noninvasive techniques and examine how this information may be used to understand aging trajectories, with the aim of guiding individual- and population-level interventions to promote healthy aging.

中文翻译：

跟踪心血管系统生物衰老的无创技术：JACC 家族系列

人口老龄化是当今时代最重要的人口变化之一。延长“健康寿命”（健康寿命的比例）是全球的首要任务。生物衰老包括多年的分子和细胞改变，最终导致多个器官系统的生理逐渐衰退，并容易患上与年龄相关的疾病。心血管疾病是老年人健康状况不佳和过早死亡的主要原因。生物衰老发生的速度因同一年龄的个体而异，并且受到广泛的遗传和环境暴露的影响。作者回顾了生物心血管衰老的特征及其使用成像和其他非侵入性技术捕获的特征，并研究了如何利用这些信息来了解衰老轨迹，目的是指导个人和人群层面的干预措施，以促进健康老龄化。

更新日期：2024-04-08

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