Aging in Heart Failure: Embracing Biology Over Chronology: JACC Family Series,JACC: Heart Failure

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Aging in Heart Failure: Embracing Biology Over Chronology: JACC Family Series
JACC: Heart Failure ( IF 10.3 ) Pub Date : 2024-04-08 , DOI: 10.1016/j.jchf.2024.02.021
Parag Goyal ₁ , Mathew S Maurer ₂ , Jason Roh ₃

Affiliation

Age is among the most potent risk factors for developing heart failure and is strongly associated with adverse outcomes. As the global population continues to age and the prevalence of heart failure rises, understanding the role of aging in the development and progression of this chronic disease is essential. Although chronologic age is on a fixed course, biological aging is more variable and potentially modifiable in patients with heart failure. This review describes the current knowledge on mechanisms of biological aging that contribute to the pathogenesis of heart failure. The discussion focuses on 3 hallmarks of aging—impaired proteostasis, mitochondrial dysfunction, and deregulated nutrient sensing—that are currently being targeted in therapeutic development for older adults with heart failure. In assessing existing and emerging therapeutic strategies, the review also enumerates the importance of incorporating geriatric conditions into the management of older adults with heart failure and in ongoing clinical trials.

中文翻译：

心力衰竭中的衰老：拥抱生物学而不是时间顺序：JACC 家庭系列

年龄是发生心力衰竭的最有力的危险因素之一，并且与不良后果密切相关。随着全球人口持续老龄化和心力衰竭患病率上升，了解衰老在这种慢性疾病的发生和进展中的作用至关重要。尽管实际年龄是固定的，但心力衰竭患者的生物衰老变化更大，并且可能是可以改变的。这篇综述描述了目前关于导致心力衰竭发病机制的生物衰老机制的知识。讨论重点关注衰老的三个标志——蛋白质稳态受损、线粒体功能障碍和营养感应失调——目前这些标志是老年心力衰竭患者治疗开发的目标。在评估现有和新兴的治疗策略时，该综述还列举了将老年疾病纳入老年心力衰竭患者的治疗和正在进行的临床试验的重要性。

更新日期：2024-04-08

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