: Berbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. Other pharmacological attributes ascribed to Ber included cardioprotective, anti-diabetic, anti-inflammatory, antimalarial, antioxidant, anti-hypercholesterolemic, and anti-allergic. Moreover, the synergistic effect of Ber improved the therapeutic potential of different drugs (paclitaxel (PTL), gemcitabine, dexamethasone, doxorubicin (DOX), and celecoxib) in different models. Various attempts could fabricate biologically active derivatives of Ber, such as 4-chlorobenzoyl berbamine (CBB) and O-4- ethoxyl-butyl-berbamine (EBB). The review focuses on the medicinal applications of Ber, particularly anti-cancer, cardioprotective, and anti-inflammatory, along with the mechanism of action.

中文翻译：

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小檗胺的药理和治疗潜力：小檗属的一种有效生物碱

：小檗胺 (Ber) 是一种活性药用双苄基异喹啉生物碱，通常从小檗属（小檗科）的不同植物中提取，在传统中医和阿育吠陀医学体系中用于治疗各种疾病。大量的体外和体内研究揭示了 Ber 通过上调促凋亡（Bax、p53）和下调抗凋亡来对抗不同细胞系（SMMC-7721、A549、MDA-MB-231 和 K562）的凋亡和细胞毒性潜力。 -凋亡（Bcl-2、生存素）蛋白。 Ber 的其他药理学特性包括心脏保护、抗糖尿病、抗炎、抗疟、抗氧化剂、抗高胆固醇血症和抗过敏。此外，Ber 的协同作用提高了不同药物（紫杉醇（PTL）、吉西他滨、地塞米松、阿霉素（DOX）和塞来昔布）在不同模型中的治疗潜力。各种尝试可以制造具有生物活性的小檗胺衍生物，例如4-氯苯甲酰小檗胺(CBB)和O-4-乙氧基丁基小檗胺(EBB)。该综述重点关注 Ber 的医学应用，特别是抗癌、心脏保护和抗炎及其作用机制。