Liver resection is an essential component of the management of patients with various primary or metastatic liver cancers, and many of these procedures can now be conducted laparoscopically. Nonetheless, whether hemihepatectomy (the resection of either the entire right or left side of the liver) can also be conducted laparoscopically without compromising oncological outcomes remains to be determined. Now, data from the phase III ORANGE II PLUS trial confirm the feasibility of and demonstrate improved functional recovery with the laparoscopic approach.

A total of 332 patients requiring hemihepatectomy (85% for cancer indications) were randomly allocated (1:1) to undergo either a laparoscopic or open procedure. Among patients with cancer, the majority (50% of the entire cohort) had metastases from colorectal cancer, 22.1% had primary hepatocellular carcinoma and 14.2% had cholangiocarcinoma. Time to functional recovery was the primary end point.

肝切除术是治疗各种原发性或转移性肝癌患者的重要组成部分，其中许多手术现在可以通过腹腔镜进行。尽管如此，半肝切除术（切除整个右侧或左侧肝脏）是否也可以在腹腔镜下进行而不影响肿瘤学结果仍有待确定。现在，来自 III 期 ORANGE II PLUS 试验的数据证实了腹腔镜方法的可行性，并证明了腹腔镜方法可改善功能恢复。

总共 332 名需要半肝切除术的患者（85% 为癌症适应症）被随机分配（1:1）接受腹腔镜手术或开腹手术。在癌症患者中，大多数（占整个队列的 50%）患有结直肠癌转移，22.1% 患有原发性肝细胞癌，14.2% 患有胆管癌。功能恢复时间是主要终点。