Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery,Small Methods

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Rational Design of Coordination Polymers Composited Hollow Multishelled Structures for Drug Delivery
Small Methods ( IF 10.7 ) Pub Date : 2024-04-28 , DOI: 10.1002/smtd.202301664
Qian Xiao _{1,

2,

3} , Lingling Shang _{1,

2,

3} , Yang Peng ₄ , Ludan Zhang ₄ , Yanze Wei _{1,

2} , Decai Zhao _{1,

2} , Yasong Zhao _{1,

2} , Jiawei Wan _{1,

2,

3} , Yuguang Wang ₄ , Dan Wang _{1,

2,

3}

Affiliation

Multifunctional drug delivery systems (DDS) are in high demand for effectively targeting specific cells, necessitating excellent biocompatibility, precise release mechanisms, and sustained release capabilities. The hollow multishelled structure (HoMS) presents a promising solution, integrating structural and compositional design for efficient DDS development amidst complex cellular environments. Herein, starting from a Fe-based metal-organic framework (MOF), amorphous coordination polymers (CP) composited HoMS with controlled shell numbers are fabricated by balancing the rate of MOF decomposition and shell formation. Fe-CP HoMS loaded with DOX is utilized for synergistic chemotherapy and chemodynamic therapy, offering excellent responsive drug release capability (excellent pH-triggered drug release 82% within 72 h at pH 5.0 solution with doxorubicin (DOX) loading capacity of 284 mg g⁻¹). In addition to its potent chemotherapy attributes, Fe-CP-HoMS possesses chemodynamic therapy potential by continuously catalyzing H₂O₂ to generate ·OH species within cancer cells, thus effectively inhibiting cancer cell proliferation. DOX@3S-Fe-CP-HoMS, at a concentration of 12.5 µg mL⁻¹, demonstrates significant inhibitory effects on cancer cells while maintaining minimal cytotoxicity toward normal cells. It is envisioned that CP-HoMS could serve as an effective and biocompatible platform for the advancement of intelligent drug delivery systems in the realm of cancer therapy.

中文翻译：

用于药物输送的配位聚合物复合空心多壳结构的合理设计

多功能药物递送系统（DDS）能够有效靶向特定细胞，因此需要优异的生物相容性、精确的释放机制和缓释能力。中空多壳结构 (HoMS) 提供了一种有前景的解决方案，它将结构和成分设计集成在一起，可在复杂的细胞环境中实现高效的 DDS 开发。在此，从铁基金属有机骨架（MOF）开始，通过平衡MOF分解速率和壳形成速率，制备了具有受控壳数的非晶配位聚合物（CP）复合HoMS。负载 DOX 的 Fe-CP HoMS 用于协同化疗和化学动力学治疗，具有出色的响应性药物释放能力（在 pH 5.0 溶液中，72 小时内，pH 触发的药物释放出色，达 82%，阿霉素 (DOX) 负载能力为 284 mg g ^{- 1} ）。除了其有效的化疗特性外，Fe-CP-HoMS还具有化学动力学治疗潜力，通过持续催化H ₂ O ₂在癌细胞内产生·OH物种，从而有效抑制癌细胞增殖。 DOX@3S-Fe-CP-HoMS，浓度为12.5 µg mL ^-1时，对癌细胞具有显着的抑制作用，同时对正常细胞保持最小的细胞毒性。预计 CP-HoMS 可以作为一个有效且生物相容的平台，促进癌症治疗领域智能药物输送系统的发展。

更新日期：2024-04-28

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