Tenascin-C (TNC) is a matricellular and multimodular glycoprotein highly expressed under pathological conditions, especially in cancer and chronic inflammatory diseases. Since a long time TNC is considered as a promising target for diagnostic and therapeutic approaches in anti-cancer treatments and was already extensively targeted in clinical trials on cancer patients. This review provides an overview of the current most advanced strategies used for TNC detection and anti-TNC theranostic approaches including some advanced clinical strategies. We also discuss novel treatment protocols, where targeting immune modulating functions of TNC could be center stage.

中文翻译：

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Tenascin-C 癌症靶向策略


Tenascin-C (TNC) 是一种基质细胞和多模块糖蛋白，在病理条件下高度表达，特别是在癌症和慢性炎症性疾病中。长期以来，TNC 被认为是抗癌治疗中诊断和治疗方法的有希望的靶标，并且已经广泛用于癌症患者的临床试验。本综述概述了当前用于 TNC 检测和抗 TNC 治疗诊断方法的最先进策略，包括一些先进的临床策略。我们还讨论了新的治疗方案，其中靶向 TNC 的免疫调节功能可能是中心舞台。