Background Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome characterized by cognitive complaints and slow gait, may have an underlying vascular etiology. Elevated blood levels of homocysteine, a known vascular risk factor, have been linked to physical and cognitive decline in older adults, though the relationship with MCR is unknown. We aimed to identify the association between homocysteine and MCR risk. Methods We examined the association between baseline homocysteine levels and incident MCR using Cox proportional hazard models in 1,826 community-dwelling older adults (55% female) from two cohorts (Einstein Aging Study [EAS] and Quebec Longitudinal Study on Nutrition and Successful Aging [NuAge]). We calculated hazard ratios (HR) with 95% confidence intervals (CI), for each cohort as well as stratified by sex and vascular disease/risk factors. Results Median follow-up time was 2.2 years in EAS and 3.0 years in NuAge. Individuals with elevated baseline homocysteine levels (> 14 µmol/L) had a significantly higher risk of incident MCR compared to those with normal levels in NuAge (HR 1.41, 95% CI = 1.01-1.97, p = .04), after adjusting for covariates. Our exploratory stratified analyses found that these associations were significant only in men with vascular disease/risk factors. Conclusions Higher blood homocysteine levels are associated with increased risk of developing MCR in older adults, particularly in men with vascular disease or vascular risk factors.

中文翻译：

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血液同型半胱氨酸升高会增加发生运动认知风险综合征的风险：一项两项队列研究


背景 运动认知风险 (MCR) 综合征是一种痴呆前期综合征，其特征是认知不适和步态缓慢，可能有潜在的血管病因。同型半胱氨酸（一种已知的血管危险因素）血液水平升高与老年人的身体和认知能力下降有关，但与 MCR 的关系尚不清楚。我们的目的是确定同型半胱氨酸与 MCR 风险之间的关联。方法 我们使用 Cox 比例风险模型，对来自两个队列的 1,826 名社区居住老年人（55% 女性）研究了基线同型半胱氨酸水平与事件 MCR 之间的关联（爱因斯坦衰老研究 [EAS] 和魁北克营养与成功老龄化纵向研究 [NuAge] ]）。我们计算了每个队列的风险比 (HR) 和 95% 置信区间 (CI)，并按性别和血管疾病/风险因素进行分层。结果 EAS 的中位随访时间为 2.2 年，NuAge 的中位随访时间为 3.0 年。调整后，与 NuAge 中同型半胱氨酸水平正常的个体相比，基线同型半胱氨酸水平升高 (> 14 µmol/L) 的个体发生 MCR 的风险显着更高（HR 1.41，95% CI = 1.01-1.97，p = .04）对于协变量。我们的探索性分层分析发现，这些关联仅在患有血管疾病/危险因素的男性中显着。结论 较高的血液同型半胱氨酸水平与老年人发生 MCR 的风险增加相关，特别是患有血管疾病或血管危险因素的男性。