The wounds, arises from accidents, burns, surgeries, diabetes, and trauma, can significantly impact well‐being and present persistent clinical challenges. Ideal wound dressings should be flexible, stable, antibacterial, antioxidant and anti‐inflammatory in nature, facilitating a scarless rapid wound healing. Initiatives were taken to create antibacterial cotton fabrics by incorporating agents like antibiotics and metallic nanoparticles. However, due to a lack of multifunctionality, these materials were not highly effective in causing scarless and rapid wound healing. In this article, nickel thiocyanate nanoparticle (NiSCN‐NPs) impregnated cotton gauze wound dressing (NiSCN‐CG) was developed. These nanoparticles were non‐toxic to normal human cell lines till 1 mg/mL dose and did not cause skin irritation in the rat model. Further, NiSCN‐NPs exhibited antimicrobial, antibiofilm and antioxidant activities confirmed using different in vitro experiments. In vivo wound healing studies in rat models using NiSCN‐CG demonstrated rapid scarless wound healing. The nickel thiocyanate impregnated cotton gauze presents a novel approach in scarless wound healing, and as an antimicrobial agent, offering a promising solution for diverse wounds and infections in the future.

中文翻译：

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硫氰酸镍纳米粒子浸渍棉纱布作为抗菌剂、抗菌膜、抗氧化剂和伤口愈合剂的多功能（四合一）治疗应用

事故、烧伤、手术、糖尿病和创伤造成的伤口会严重影响健康并带来持续的临床挑战。理想的伤口敷料应具有柔韧、稳定、抗菌、抗氧化和抗炎等特性，促进伤口快速无疤愈合。人们采取了一些措施，通过加入抗生素和金属纳米粒子等物质来制造抗菌棉织物。然而，由于缺乏多功能性，这些材料在实现无疤痕和快速伤口愈合方面效果不佳。在本文中，开发了硫氰酸镍纳米颗粒（NiSCN-NPs）浸渍棉纱布伤口敷料（NiSCN-CG）。这些纳米粒子在 1 mg/mL 剂量下对正常人类细胞系无毒，并且不会对大鼠模型造成皮肤刺激。此外，不同的体外实验证实，NiSCN-NPs 表现出抗菌、抗生物膜和抗氧化活性。使用 NiSCN-CG 在大鼠模型中进行的体内伤口愈合研究表明，伤口可以快速无疤痕愈合。硫氰酸镍浸渍棉纱布提出了一种无疤痕伤口愈合的新方法，并且作为抗菌剂，为未来的各种伤口和感染提供了一种有前景的解决方案。