Prussian Blue/Polydopamine-Decorated Halloysite Nanotubes for Effective Bacterial Eradication via Photothermal-Enhanced Chemodynamic Therapy,ACS Applied Nano Materials

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Prussian Blue/Polydopamine-Decorated Halloysite Nanotubes for Effective Bacterial Eradication via Photothermal-Enhanced Chemodynamic Therapy
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-04-25 , DOI: 10.1021/acsanm.4c00824
Jie Chen ₁ , Qinqin Zhang ₁ , Chenyang Qi ₁ , Yipin Zhang ₁ , Fuqiang Shi ₁ , Jing Tu ₁

Affiliation

Bacterial infectious diseases seriously threaten global public health. The inappropriate use of antibiotics promoted the emergence and widespread of drug-resistant bacteria; thus, nanomaterial-based antibacterial agents are considered promising alternatives to combat bacterial infections. Herein, a near-infrared (NIR) light and hydrogen peroxide (H₂O₂) dually triggered halloysite nanotube (HNT)-based nanoplatform (HNTs@PDA/PB) as a broad-spectrum antibacterial agent was fabricated via a facile two-step strategy. Specifically, as natural clay materials, HNTs were first coated with a versatile layer of polydopamine (PDA). Then, the catechol groups on the PDA surface served as a chelating and reducing agent, facilitating the in situ growth of Prussian blue (PB) nanoparticles. The as-prepared HNTs@PDA/PB exhibited strong absorption in the NIR region and peroxidase-like activity, which suggested that it can act as a photothermal and Fenton dual-modal agent. Under NIR irradiation and exogenous H₂O₂, HNTs@PDA/PB exhibited excellent bactericidal activity via photothermal-enhanced chemodynamic therapy against multiple pathogenic bacteria, eliminating 68.0 ± 0.4% of the Staphylococcus aureus biofilm and 61.6 ± 0.3% of the methicillin-resistant S. aureus (MRSA) biofilm. In vivo studies further demonstrated that HNTs@PDA/PB could achieve efficient bacterial eradication and accelerate wound healing. Overall, this versatile HNT-based nanoplatform can serve as a promising therapeutic candidate to fight against bacterial infectious diseases.

中文翻译：

普鲁士蓝/聚多巴胺装饰的埃洛石纳米管通过光热增强化学动力学疗法有效消灭细菌

细菌传染病严重威胁全球公共卫生。抗生素的不当使用促进了耐药菌的出现和广泛传播；因此，基于纳米材料的抗菌剂被认为是对抗细菌感染的有前途的替代品。在此，通过简单的两步法制备了近红外（NIR）光和过氧化氢（H ₂ O ₂）双重触发的基于埃洛石纳米管（HNT）的纳米平台（HNTs@PDA/PB）作为广谱抗菌剂。阶梯策略。具体来说，作为天然粘土材料，HNT 首先涂有一层多功能的聚多巴胺 (PDA)。然后，PDA 表面的儿茶酚基团充当螯合剂和还原剂，促进普鲁士蓝（PB）纳米颗粒的原位生长。所制备的 HNTs@PDA/PB 在近红外区域表现出强吸收和类似过氧化物酶的活性，这表明它可以作为光热和芬顿双模式试剂。在近红外辐射和外源H ₂ O ₂下，HNTs@PDA/PB 通过光热增强化学动力学疗法对多种病原菌表现出优异的杀菌活性，消除了 68.0 ± 0.4% 的金黄色葡萄球菌生物膜和 61.6 ± 0.3% 的耐甲氧西林细菌金黄色葡萄球菌(MRSA) 生物膜。体内研究进一步证明HNTs@PDA/PB可以实现有效的细菌根除并加速伤口愈合。总体而言，这种基于 HNT 的多功能纳米平台可以作为对抗细菌传染病的有前途的治疗候选药物。

更新日期：2024-04-25

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