<br>三响应、多模式、视觉电子皮肤对妊娠糖尿病的一体化健康管理,ACS Sensors

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三响应、多模式、视觉电子皮肤对妊娠糖尿病的一体化健康管理
ACS Sensors ( IF 8.2 ) Pub Date : 2024-04-26 , DOI: 10.1021/acssensors.4c00426
Yue Wu _{1,

2} , Yong Liu ₁ , Xueting Yang ₁ , Mingqiong Tong ₁ , Xubao Jiang ₂ , Xiangling Gu ₁

Affiliation

妊娠糖尿病（GDM）是妊娠期最常见的代谢性疾病之一，会导致孕妇严重并发症并威胁婴儿的生命安全。因此，建立孕妇重要生理指标的多用途监测途径显得尤为重要。在这项工作中，用聚乙烯醇（PVA）、硼砂和具有不同甲基（甲基纤维素，MC）、羟丙基（羟丙基纤维素，HPC）或两者取代基的纤维素醚制备了三种双网络水凝胶（羟丙基甲基纤维素，HPMC）。水凝胶相应的韧性（143.9、102.3和135.9 kJ cm ^–3 ）和电导率（0.69、0.45和0.51 S m ^–1 ）表明PB-MC具有突出的性能。分子动力学模拟进一步揭示了PVA和纤维素醚之间的氢键相互作用在调节水凝胶的结构和性能中发挥关键作用的本质。随后掺杂热致变色胶囊粉末（TCP）以获得复合水凝胶（TCPs@PB-MC）来指示人体温度的变化。此外，通过电化学窗口深入跟踪了 TCPs@PB-MC 对葡萄糖、pH 和温度的响应过程。这项工作为 GDM 的一体化健康管理提供了一种新的策略。

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Triple-Responsive, Multimodal, Visual Electronic Skin toward All-in-One Health Management for Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy, leading to serious complications for pregnant women and a threat to life safety of infants. Therefore, it is particularly important to establish a multipurpose monitoring pathway to important physiological indicators of pregnant women. In this work, three kinds of double network hydrogels are prepared with poly(vinyl alcohol) (PVA), borax, and cellulose ethers with varying substituents of methyl (methyl cellulose, MC), hydroxypropyl (hydroxypropyl cellulose, HPC), or both (hydroxypropyl methyl cellulose, HPMC), respectively. The corresponding toughness (143.9, 102.3, and 135.9 kJ cm^–3) and conductivity (0.69, 0.45, and 0.51 S m^–1) of the hydrogels demonstrate that PB-MC was endowed with the prominent performance. Molecular dynamics simulations further revealed the essence that hydrogen bond interactions between PVA and cellulose ethers play a critical role in regulating the structure and properties of hydrogels. Thermochromic capsule powders (TCPs) were subsequently doped in to achieve a composite hydrogel (TCPs@PB-MC) to indicate the change in human body temperature. Furthermore, the process of the TCPs@PB-MC response to glucose, pH, and temperature was tracked in-depth through the electrochemical window. This work provides a novel strategy for all-in-one health management of GDM.

更新日期：2024-04-26

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