This review paper provides a comprehensive overview of recent advancements in the synthesis, reactivity, and applications of N-isoindoline-1,3-dione heterocycles. These aromatic compounds, characterized by an isoindoline nucleus and carbonyl groups at positions 1 and 3, have gained significant attention for their potential use in diverse fields such as pharmaceutical synthesis, herbicides, colorants, dyes, polymer additives, organic synthesis, and photochromic materials. The review focuses on the period from 2015 to 2024, highlighting the diverse synthetic strategies employed to access N-isoindoline-1,3-diones derivatives. This review discusses the innovative methodologies and transformations that have enabled the efficient construction of these compounds with various substitution patterns. Furthermore, the reactivity of N-isoindoline-1,3-diones and their potential applications in different fields are explored. The paper emphasizes the importance of understanding the structure–activity relationships and biological properties of N-isoindoline-1,3-dione derivatives, with the aim of unlocking their potential as therapeutic agents. Additionally, the review underscores the need for sustainable and environmentally friendly synthetic approaches in this field.

该综述全面概述了N-异吲哚啉-1,3-二酮杂环的合成、反应性和应用的最新进展。这些芳香族化合物以异吲哚啉核和1位和3位羰基为特征，因其在药物合成、除草剂、着色剂、染料、聚合物添加剂、有机合成和光致变色材料等不同领域的潜在应用而受到广泛关注。该综述重点关注 2015 年至 2024 年期间，强调了用于获取N-异吲哚啉-1,3-二酮衍生物的多种合成策略。本综述讨论了创新方法和转化，这些方法和转化使得能够以各种取代模式有效构建这些化合物。此外，还探讨了N-异吲哚啉-1,3-二酮的反应性及其在不同领域的潜在应用。该论文强调了了解N-异吲哚啉-1,3-二酮衍生物的结构-活性关系和生物学特性的重要性，目的是释放其作为治疗剂的潜力。此外，该评论强调了该领域需要可持续和环境友好的合成方法。