Bioorthogonal Cu Single-Atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis and Immunotherapy,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bioorthogonal Cu Single-Atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis and Immunotherapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-04-23 , DOI: 10.1002/anie.202405937
Luyan Wu ₁ , Huihui Lin _{2,

3} , Xiang Cao ₄ , Qiang Tong ₁ , Fangqi Yang ₁ , Yinxing Miao ₅ , Deju Ye ₅ , Quli Fan ₁

Affiliation

We have developed bioorthogonal Cu single atom nanozyme (CuSACO) for specifically tumor-targeting and photoacoustic (PA) imaging-guided tumor multifunctional therapy including high-efficiency multienzyme catalytic activities (catalase (CAT), oxidase (OXD), peroxidase (POD)), photothermal therapy (PTT), cuproptosis and immunogenic cell death (ICD)-based immunotherapy, which effectively curb the growth, metastasis and recurrence of tumors.

中文翻译：

用于协同纳米催化疗法、光热疗法、Cuprotosis 和免疫疗法的生物正交铜单原子纳米酶

我们开发了生物正交铜单原子纳米酶（CuSACO），专门用于肿瘤靶向和光声（PA）成像引导的肿瘤多功能治疗，包括高效多酶催化活性（过氧化氢酶（CAT）、氧化酶（OXD）、过氧化物酶（POD））、光热疗法（PTT）、铜凋亡和免疫原性细胞死亡（ICD）为主的免疫疗法，有效抑制肿瘤的生长、转移和复发。

更新日期：2024-04-23

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南