Hydrogels are distinguished by their exceptional ability to absorb and retain large volumes of water within their complex three‐dimensional polymer networks, which is advantageous for the development of intraocular lenses (IOLs). Their innate hydrophilicity offers an optimal substrate for the fabrication of IOLs that simulate the natural lens' accommodation, thereby reducing irritation and facilitating healing after surgery. The swelling and water retention characteristics of hydrogels contribute to their notable biocompatibility and versatile mechanical properties. However, the clinical application of hydrogels faces challenges, including managing potential adverse postimplantation effects. Rigorous research is essential to ascertain the safety and effectiveness of hydrogels. This review systematically examines the prospects and constraints of hydrogels as innovative materials for IOLs. Our comprehensive analysis examines their inherent properties, various classification strategies, cross‐linking processes, and sensitivity to external stimuli. Additionally, we thoroughly evaluate their interactions with ocular tissues, underscoring the potential for hydrogels to be refined into seamless and biologically integrated visual aids. We also discuss the anticipated technological progress and clinical uses of hydrogels in IOL manufacturing. With ongoing technological advancements, the promise of hydrogels is poised to evolve from concept to clinical reality, marking a significant leap forward in ophthalmology characterized by improved patient comfort, enhanced functionality, and reliable safety.

中文翻译：

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未来之眼：解锁水凝胶在人工晶状体中的潜在用途


水凝胶的特点是在其复杂的三维聚合物网络中吸收和保留大量水的特殊能力，这有利于人工晶状体 （IOL） 的发展。它们与生俱来的亲水性为制造模拟天然晶状体调节的人工晶状体提供了最佳基材，从而减少刺激并促进手术后的愈合。水凝胶的溶胀和保水特性有助于其显著的生物相容性和多种机械性能。然而，水凝胶的临床应用面临挑战，包括管理潜在的植入后不良影响。严格的研究对于确定水凝胶的安全性和有效性至关重要。本文系统研究了水凝胶作为 IOL 创新材料的前景和限制。我们的综合分析检查了它们的固有特性、各种分类策略、交联过程和对外部刺激的敏感性。此外，我们彻底评估了它们与眼组织的相互作用，强调了水凝胶被提炼成无缝和生物整合的视觉辅助工具的潜力。我们还讨论了水凝胶在 IOL 制造中的预期技术进展和临床应用。随着技术的不断进步，水凝胶的前景有望从概念演变为临床现实，标志着眼科医学的重大飞跃，其特点是提高患者舒适度、增强功能和可靠的安全性。