The biggest obstacle to treating wound healing continues to be the production of simple, inexpensive wound dressings that satisfy the demands associated with full process of repair at the same time. Herein, a series of injectable composite hydrogels were successfully prepared by a one-pot method by utilizing the Schiff base reaction as well as hydrogen bonding forces between hydroxypropyl chitosan (HCS), ε-poly--lysine (EPL), and 2,3,4-trihydroxybenzaldehyde (TBA), and multiple cross-links formed by the reversible coordination between iron (III) and pyrogallol moieties. Notably, hydrogel exhibits excellent physicochemical properties, including injectability, self-healing, water retention, and adhesion, which enable to fill irregular wounds for a long period, providing a suitable moist environment for wound healing. Interestingly, the excellent hemostatic properties of the hydrogel can quickly stop bleeding and avoid the serious sequelae of massive blood loss in acute trauma. Moreover, the powerful antimicrobial and antioxidant properties also protect against bacterial infections and reduce inflammation at the wound site, thus promoting healing at all stages of the wound. The study of biohydrogel with multifunctional integration of wound treatment and smart medical treatment is clarified by this line of research.

中文翻译：

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羟丙基壳聚糖/ε-聚-L-赖氨酸基可注射和自愈水凝胶，具有抗菌和止血活性，用于伤口修复


治疗伤口愈合的最大障碍仍然是生产简单、廉价的伤口敷料，同时满足与整个修复过程相关的需求。在此，利用希夫碱反应以及羟丙基壳聚糖（HCS）、ε-聚赖氨酸（EPL）和2,3之间的氢键作用，通过一锅法成功制备了一系列可注射的复合水凝胶。 ,4-三羟基苯甲醛 (TBA)，以及由铁 (III) 和连苯三酚部分之间可逆配位形成的多个交联。值得注意的是，水凝胶具有优异的理化特性，包括可注射性、自愈性、保水性和粘附性，能够长期填充不规则伤口，为伤口愈合提供合适的湿润环境。有趣的是，水凝胶优异的止血性能可以快速止血，避免急性创伤中大量失血的严重后遗症。此外，强大的抗菌和抗氧化特性还可以防止细菌感染并减少伤口部位的炎症，从而促进伤口各个阶段的愈合。该研究阐明了集伤口治疗和智能医疗多功能为一体的生物水凝胶的研究。