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Cell membrane-coated nanoparticles for targeting carcinogenic bacteria
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-21 , DOI: 10.1016/j.addr.2024.115320 Lei Sun 1 , Dan Wang 1 , Kailin Feng 1 , Jiayuan Alex Zhang 1 , Weiwei Gao 1 , Liangfang Zhang 1
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-04-21 , DOI: 10.1016/j.addr.2024.115320 Lei Sun 1 , Dan Wang 1 , Kailin Feng 1 , Jiayuan Alex Zhang 1 , Weiwei Gao 1 , Liangfang Zhang 1
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The etiology of cancers is multifactorial, with certain bacteria established as contributors to carcinogenesis. As the understanding of carcinogenic bacteria deepens, interest in cancer treatment through bacterial eradication is growing. Among emerging antibacterial platforms, cell membrane-coated nanoparticles (CNPs), constructed by enveloping synthetic substrates with natural cell membranes, exhibit significant promise in overcoming challenges encountered by traditional antibiotics. This article reviews recent advancements in developing CNPs for targeting carcinogenic bacteria. It first summarizes the mechanisms of carcinogenic bacteria and the status of cancer treatment through bacterial eradication. Then, it reviews engineering strategies for developing highly functional and multitasking CNPs and examines the emerging applications of CNPs in combating carcinogenic bacteria. These applications include neutralizing virulence factors to enhance bacterial eradication, exploiting bacterium-host binding for precise antibiotic delivery, and modulating antibacterial immunity to inhibit bacterial growth. Overall, this article aims to inspire technological innovations in developing CNPs for effective cancer treatment through oncogenic bacterial targeting.
中文翻译：
用于靶向致癌细菌的细胞膜涂层纳米颗粒
癌症的病因是多因素的，某些细菌被认为是致癌的因素。随着对致癌细菌了解的加深，人们对通过根除细菌治疗癌症的兴趣日益浓厚。在新兴的抗菌平台中，细胞膜涂层纳米颗粒（CNP）是通过用天然细胞膜包裹合成基质而构建的，在克服传统抗生素遇到的挑战方面表现出巨大的前景。本文回顾了开发针对致癌细菌的 CNP 的最新进展。首先总结了致癌细菌的机制以及通过根除细菌治疗癌症的现状。然后，回顾了开发高功能和多任务 CNP 的工程策略，并研究了 CNP 在对抗致癌细菌方面的新兴应用。这些应用包括中和毒力因子以增强细菌根除、利用细菌-宿主结合来精确递送抗生素以及调节抗菌免疫以抑制细菌生长。总体而言，本文旨在激发技术创新，开发 CNP，通过致癌细菌靶向有效治疗癌症。
更新日期：2024-04-21
中文翻译：
用于靶向致癌细菌的细胞膜涂层纳米颗粒
癌症的病因是多因素的，某些细菌被认为是致癌的因素。随着对致癌细菌了解的加深，人们对通过根除细菌治疗癌症的兴趣日益浓厚。在新兴的抗菌平台中，细胞膜涂层纳米颗粒（CNP）是通过用天然细胞膜包裹合成基质而构建的，在克服传统抗生素遇到的挑战方面表现出巨大的前景。本文回顾了开发针对致癌细菌的 CNP 的最新进展。首先总结了致癌细菌的机制以及通过根除细菌治疗癌症的现状。然后，回顾了开发高功能和多任务 CNP 的工程策略，并研究了 CNP 在对抗致癌细菌方面的新兴应用。这些应用包括中和毒力因子以增强细菌根除、利用细菌-宿主结合来精确递送抗生素以及调节抗菌免疫以抑制细菌生长。总体而言，本文旨在激发技术创新，开发 CNP，通过致癌细菌靶向有效治疗癌症。
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