A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing,Advanced Functional Materials

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A Multifunctional Hydrogel with Photothermal Antibacterial and AntiOxidant Activity for Smart Monitoring and Promotion of Diabetic Wound Healing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-04-21 , DOI: 10.1002/adfm.202402531
Yue Wang ₁ , Kun Liu ₁ , Wenying Wei ₁ , Honglian Dai _{1,

2}

Affiliation

Persistent oxidative stress and bacterial infection are significant challenges that impede diabetic wound healing. By combining diagnosis and treatment, pH variation on the wound tissue can be monitored in real time, and precise treatment can be carried out promptly to promote diabetic wound healing. In this study, a lipoic acid-modified chitosa (LAMC) hydrogel is constructed via an amidation reaction, and ceria oxide-molybdenum disulfide nanoparticles with a polydopamine layer (C@M@P), along with carbon quantum dots (CDs) synthesized by a hydrothermal method, are loaded into the hydrogel, thus developing a diagnostic and therapeutic hydrogel (LAMC/CD-C@M@P). By incorporating CDs, the hydrogel exhibits high sensitivity and reversibility to pH under ultraviolet light. Furthermore, the images of hydrogels can be collected using smartphones and converted into wound pH signals, providing a means for early detection of bacterial infection. Notably, the LAMC/CD-C@M@P hydrogel exhibits excellent photothermal antibacterial capability against Staphylococcus aureus and Escherichia coli and remarkable antioxidant and anti-inflammatory abilities to alleviate reactive oxygen species and relieve inflammation response. In summary, this multifunctional hydrogel offers great potential as an innovative wound dressing platform, representing a significant advancement in chronic wound management.

中文翻译：

具有光热抗菌和抗氧化活性的多功能水凝胶，用于智能监测和促进糖尿病伤口愈合

持续的氧化应激和细菌感染是阻碍糖尿病伤口愈合的重大挑战。通过诊治结合，实时监测创面组织的pH变化，及时进行精准治疗，促进糖尿病创面愈合。在这项研究中，通过酰胺化反应构建了硫辛酸修饰的壳聚糖（LAMC）水凝胶，以及具有聚多巴胺层（C@M@P）的二氧化铈-二硫化钼纳米粒子，以及通过合成的碳量子点（CD）通过水热方法将其加载到水凝胶中，从而开发出诊断和治疗水凝胶（LAMC/CD-C@M@P）。通过掺入 CD，水凝胶在紫外光下表现出对 pH 值的高敏感性和可逆性。此外，可以使用智能手机收集水凝胶图像并将其转换为伤口 pH 信号，为早期检测细菌感染提供手段。值得注意的是，LAMC/CD-C@M@P水凝胶对金黄色葡萄球菌和大肠杆菌表现出优异的光热抗菌能力，并具有显着的抗氧化和抗炎能力，可减轻活性氧并缓解炎症反应。总之，这种多功能水凝胶作为创新伤口敷料平台具有巨大潜力，代表了慢性伤口管理的重大进步。

更新日期：2024-04-21

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