Reprogramming of methionine metabolism is a conserved hallmark of tumorigenesis. Recent studies have revealed mechanisms regulating methionine metabolism within the tumor microenvironment (TME) that drive both cancer development and antitumor immunity evasion. In this review article we summarize advancements in our understanding of tumor regulation of methionine metabolism and therapies in development that target tumor methionine metabolism. We also delineate the challenges of methionine blockade therapies in cancer and discuss emerging strategies to address them.

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针对癌症中的蛋氨酸代谢：机遇与挑战

蛋氨酸代谢的重编程是肿瘤发生的保守标志。最近的研究揭示了肿瘤微环境（TME）内调节蛋氨酸代谢的机制，这些机制驱动癌症发展和抗肿瘤免疫逃避。在这篇综述文章中，我们总结了我们对肿瘤蛋氨酸代谢调节的理解的进展以及针对肿瘤蛋氨酸代谢的治疗方法的开发。我们还描述了蛋氨酸阻断疗法在癌症中面临的挑战，并讨论了解决这些问题的新兴策略。