In this issue of Chem Catalysis, Ye and co-workers present a bisguanidinium-catalyzed method involving an intramolecular carbonyl 1,2-transposition for the remote enantioselective desymmetrization of prochiral cyclohexanone. The comprehensive mechanistic experiments, coupled with density functional theory (DFT) calculations, lay a robust foundation for future advancements in functional-group transposition.

中文翻译：

---

环己酮羰基 1,2-转位的远程对映选择性去对称化

在本期《化学催化》中，Ye 和同事提出了一种双胍催化方法，涉及分子内羰基 1,2-转座，用于前手性环己酮的远程对映选择性去对称化。全面的机理实验与密度泛函理论（DFT）计算相结合，为官能团转置的未来发展奠定了坚实的基础。