The rapid developments in the field of zeolitic imidazolate frameworks (ZIFs) in recent years have created unparalleled opportunities for the development of unique bioactive ZIFs for a range of biosensor applications. Integrating bioactive molecules such as DNA, aptamers, and antibodies into ZIFs to create bioactive ZIF composites has attracted great interest. Bioactive ZIF composites have been developed that combine the multiple functions of bioactive molecules with the superior chemical and physical properties of ZIFs. This review thoroughly summarizes the ZIFs as well as the novel strategies for incorporating bioactive molecules into ZIFs. They are used in many different applications, especially in biosensors. Finally, biosensor applications of bioactive ZIFs were investigated in optical (fluorescence and colorimetric) and electrochemical (amperometric, conductometric, and impedance) fields. The surface of ZIFs makes it easier to immobilize bioactive molecules like DNA, enzymes, or antibodies, which in turn enables the construction of cutting-edge, futuristic biosensors.

中文翻译：

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用于生物传感应用的生物活性沸石咪唑酯框架（ZIF）的最新进展和协同效应


近年来沸石咪唑酯骨架（ZIF）领域的快速发展为开发用于一系列生物传感器应用的独特生物活性ZIF创造了无与伦比的机会。将 DNA、适体和抗体等生物活性分子整合到 ZIF 中以创建生物活性 ZIF 复合材料引起了人们的极大兴趣。生物活性 ZIF 复合材料的开发将生物活性分子的多种功能与 ZIF 的优异化学和物理特性结合起来。这篇综述全面总结了 ZIF 以及将生物活性分子纳入 ZIF 的新策略。它们用于许多不同的应用，尤其是生物传感器。最后，研究了生物活性 ZIF 在光学（荧光和比色）和电化学（电流、电导和阻抗）领域的生物传感器应用。 ZIF 的表面更容易固定 DNA、酶或抗体等生物活性分子，从而能够构建尖端的、未来的生物传感器。