Most extrauterine high-grade serous carcinomas (HGSCs) are thought to develop first in the distal fallopian tube. Most models of HGSC assume origin from relatively stable, noninvasive serous tubal intraepithelial carcinomas. However, widespread tumor involvement in the absence of a serous tubal intraepithelial carcinoma could occur after catastrophic genomic events (CGEs; such as chromothripsis or polyploidy). Twenty-six HGSCs assigned to fallopian tube (n = 9, group 1) and/or ovary (n = 9, group 2), and primary peritoneal (n = 8, group 3) were assessed by microarray (Oncoscan). CGEs were identified in 15/26 (57.7%); chromothripsis-like pattern in 13/26 (50.0%) and polyploidy in 6/26 (23.1%). CGE was seen in 4/9 (44.4%), 9/9 (100%), and 2/8 (25%) cases in groups 1. 2, and 3, respectively. Overall, CGEs were seen in 9/9 (100%) cases with grossly evident ovarian parenchymal involvement versus 6/17 (35.3%) without (P = 0.0024). Ovarian size (measured on the long axis) correlated with CGE positivity (P = 0.016). CGEs are significantly more common in HGSCs with ovarian parenchymal involvement compared with those limited to the fallopian tube and/or extraovarian tissues. These associations suggest geographically different tumor growth patterns and support the subdivision of HGSCs according to not only the stage but also tumor distribution. They have implications for clinical and pathologic presentation, trajectory of tumor evolution, and in the case of primary peritoneal HGSCs, potentially unique precursors to tumor transitions that could inform or influence cancer prevention efforts.

中文翻译：

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基因组突变（染色体碎裂和多倍体）与宫外高级别浆液性癌的肿瘤分布相关。


大多数宫外高级别浆液性癌（HGSC）被认为首先在远端输卵管中发生。大多数 HGSC 模型假定起源于相对稳定、非侵袭性浆液性输卵管上皮内癌。然而，在灾难性基因组事件（CGE；例如染色体碎裂或多倍体）之后，可能会发生在没有浆液性输卵管上皮内癌的情况下广泛的肿瘤受累。通过微阵列 (Oncoscan) 评估分配给输卵管（n = 9，第 1 组）和/或卵巢（n = 9，第 2 组）和原发性腹膜（n = 8，第 3 组）的 26 个 HGSC。 CGE 的发现率为 15/26 (57.7%)； 13/26 (50.0%) 为类染色体碎裂模式，6/26 (23.1%) 为多倍体。第 1 组、第 2 组和第 3 组中分别有 4/9 (44.4%)、9/9 (100%) 和 2/8 (25%) 病例出现 CGE。总体而言，有明显卵巢实质受累的病例中有 9/9 (100%) 出现 CGE，而没有明显受累的病例中有 6/17 (35.3%) (P = 0.0024)。卵巢大小（长轴测量）与 CGE 阳性相关（P = 0.016）。与仅限于输卵管和/或卵巢外组织的 HGSC 相比，CGE 在卵巢实质受累的 HGSC 中更为常见。这些关联表明地理上不同的肿瘤生长模式，并支持不仅根据阶段而且根据肿瘤分布对 HGSC 进行细分。它们对临床和病理表现、肿瘤进化轨迹具有影响，并且就原发性腹膜 HGSC 而言，它们是肿瘤转变的潜在独特前体，可以为癌症预防工作提供信息或影响。