<br>VDR 是一种潜在的预后生物标志物，与免疫浸润呈正相关：一种具有实验验证的全面泛癌种分析。,Bioscience Reports

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VDR 是一种潜在的预后生物标志物，与免疫浸润呈正相关：一种具有实验验证的全面泛癌种分析。
Bioscience Reports ( IF 3.8 ) Pub Date : 2024-04-19 , DOI: 10.1042/bsr20231845
Xuedi Xia ₁ , Feng Xu ₁ , Dexing Dai ₁ , An Xiong ₁ , Ruoman Sun ₁ , Yali Ling ₁ , Lei Qiu ₁ , Rui Wang ₁ , Ya Ding ₁ , Miaoying Lin ₁ , Haibo Li ₁ , Zhongjian Xie ₁

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维生素 D 受体（VDR）是一种转录因子，可介导 1,25-二羟基维生素 D3 的各种生物学功能。尽管越来越多的细胞学和动物研究支持 VDR 在癌症中的抑制作用，但该结论在人类癌症中仍然存在争议，并且没有 VDR 的系统泛癌分析可用。我们基于多个公共数据库和 R 软件探讨了 33 种人类癌症中 VDR 表达与预后、免疫浸润、肿瘤微环境或基因集富集分析（GSEA）之间的关系。同时，VDR 的表达和作用在甲状腺状癌（PTC）中得到实验验证。与正常组织相比，VDR 表达在 8 种类型的癌症中降低，在 12 种类型的癌症中增加。VDR 表达增加与 13 种癌症类型的预后良好或不良相关。VDR 表达分别与 20 、 12 和 10 种癌症类型的癌症相关成纤维细胞、巨噬细胞或中性粒细胞的浸润呈正相关，并且这种相关性在 PTC 中得到了实验验证。在 24 种癌症类型中，VDR 表达增加与肿瘤微环境（TME）中基质或免疫成分百分比增加相关。VDR 正相关和负相关基因分别富集在免疫细胞功能和能量代谢途径中，排名前 9 位的高致死性肿瘤。此外，VDR 在 PTC 中的表达增加并抑制细胞增殖和迁移。总之，VDR 是一种潜在的预后生物标志物，与多种人类癌症中 TME 中的免疫浸润以及基质或免疫成分呈正相关。

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VDR is a potential prognostic biomarker and positively correlated with immune infiltration: a comprehensive pan-cancer analysis with experimental verification.

The vitamin D receptor (VDR) is a transcription factor that mediates a variety of biological functions of 1,25-dihydroxyvitamin D3. Although there is growing evidence of cytological and animal studies supporting the suppressive role of VDR in cancers, the conclusion is still controversial in human cancers and no systematic pan-cancer analysis of VDR is available. We explored the relationships between VDR expression and prognosis, immune infiltration, tumor microenvironment or gene set enrichment analysis (GSEA) in 33 types of human cancers based on multiple public databases and R software. Meanwhile, the expression and role of VDR were experimentally validated in papillary thyroid cancer (PTC). VDR expression decreased in 8 types and increased in 12 types of cancer compared to normal tissues. Increased expression of VDR was associated with either good or poor prognosis in 13 cancer types. VDR expression was positively correlated with the infiltration of cancer-associated fibroblasts, macrophages, or neutrophils in 20, 12 and 10 cancer types respectively and this correlation was experimentally validated in PTC. Increased VDR expression was associated with increased percentage of stromal or immune components in tumor microenvironment (TME) in 24 cancer types. VDR positively and negatively correlated genes were enriched in immune cell function and energy metabolism pathways respectively in the top 9 highly lethal tumors. Additionally, VDR expression was increased in PTC and inhibited cell proliferation and migration. In conclusion, VDR is a potential prognostic biomarker and positively correlated with immune infiltration as well as stromal or immune components in TME in multiple human cancers.

更新日期：2024-04-19

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