Soil-borne diseases represent an impediment to the sustainable development of agriculture. A soil-borne disease caused by Ilyonectria destructans severely impacts Panax species, and soil disinfestation has proven to be an effective management approach. Here, diallyl trisulfide (DATS), derived from garlic, exhibited pronounced inhibitory effects on the growth of I. destructans in vitro tests and contributed to the alleviation of soil-borne diseases in the field. A comprehensive analysis demonstrated that DATS inhibits the growth of I. destructans by activating detoxifying enzymes, such as GSTs, disrupting the equilibrium of redox reactions. A series of antioxidant amino acids were suppressed by DATS. Particularly noteworthy is the substantial depletion of glutathione by DATS, resulting in the accumulation of ROS, ultimately culminating in the inhibition of I. destructans growth. Briefly, DATS could effectively suppress soil-borne diseases by inhibiting pathogen growth through the activation of ROS, and it holds promise as a potential environmentally friendly soil disinfestation.

中文翻译：

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二烯丙基三硫化物通过诱导活性氧的爆发来对 Ilyonectria destructans 进行土壤消毒

土传疾病阻碍了农业的可持续发展。由Ilyonectria destructans引起的土传疾病严重影响人参物种，土壤灭虫已被证明是一种有效的管理方法。在此，从大蒜中提取的二烯丙基三硫化物（DATS）在体外测试中对I. destructans 的生长表现出显着的抑制作用，并有助于减轻田间土传疾病。综合分析表明，DATS通过激活 GST 等解毒酶，破坏氧化还原反应的平衡，从而抑制I. destructans的生长。 DATS 抑制了一系列抗氧化氨基酸。特别值得注意的是 DATS 会大量消耗谷胱甘肽，导致 ROS 积累，最终抑制I. destructans的生长。简而言之，DATS 可以通过激活 ROS 抑制病原体生长，从而有效抑制土传疾病，有望成为一种潜在的环境友好型土壤消毒剂。