Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)–N Bond Formation of Conjugated Tosyl Amides,Journal of the American Chemical Society

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Copper-Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)–N Bond Formation of Conjugated Tosyl Amides
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2013-09-18 , DOI: 10.1021/ja403954g
Wangqing Kong ₁ , Maria Casimiro ₁ , Estı́baliz Merino ₁ , Cristina Nevado ₁

Affiliation

A novel copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp(2))-N bond formation with conjugated tosyl amides as starting materials is presented here. The reaction affords α-aryl-β-trifluoromethyl amides bearing a quaternary stereocenter or trifluoromethylated oxindoles in a regioselective manner.

中文翻译：

铜催化的一锅三氟甲基化/芳基迁移/脱磺酰化和共轭甲苯磺酰胺的 C(sp2)-N 键形成

此处介绍了一种新型铜催化一锅三氟甲基化/芳基迁移/脱磺酰化和 C(sp(2))-N 键形成，以共轭甲苯磺酰胺为起始材料。该反应以区域选择性方式提供带有季立体中心或三氟甲基化羟吲哚的α-芳基-β-三氟甲基酰胺。

更新日期：2013-09-18

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