Under spatially incoherent illumination, time-domain full-field optical coherence tomography (FFOCT) offers the possibility to achieve in vivo retinal imaging at cellular resolution over a wide field of view. Such performance is possible, albeit there is the presence of ocular aberrations even without the use of classical adaptive optics. While the effect of aberrations in FFOCT has been debated these past years, mostly on low-order and static aberrations, we present, for the first time to our knowledge, a method enabling a quantitative study of the effect of statistically representative static and dynamic ocular aberrations on FFOCT image metrics, such as SNR, resolution, and image similarity. While we show that ocular aberrations can decrease FFOCT SNR and resolution by up to 14 dB and fivefold, we take advantage of such quantification to discuss different possible compromises between performance gain and adaptive optics complexity and speed, to optimize both sensor-based and sensorless FFOCT high-resolution retinal imaging.

中文翻译：

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静态和动态眼像差对全视场光学相干断层扫描在体高分辨率视网膜成像的影响

在空间不相干照明下，时域全场光学相干断层扫描（FFOCT）提供了在宽视场以细胞分辨率实现活体视网膜成像的可能性。这种性能是可能的，尽管即使不使用经典的自适应光学器件也会存在眼部像差。虽然 FFOCT 中像差的影响在过去几年中一直存在争议，主要是关于低阶和静态像差，但据我们所知，我们首次提出了一种能够对统计代表性静态和动态眼部影响进行定量研究的方法。 FFOCT 图像指标的像差，例如 SNR、分辨率和图像相似度。虽然我们证明眼睛像差可以将 FFOCT 信噪比和分辨率降低多达 14 dB 和五倍，但我们利用这种量化来讨论性能增益与自适应光学复杂性和速度之间可能的不同折衷方案，以优化基于传感器和无传感器的 FFOCT高分辨率视网膜成像。