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Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago
World Journal of Emergency Surgery ( IF 6.0 ) Pub Date : 2024-04-16 , DOI: 10.1186/s13017-024-00543-w
Gennaro Perrone 1 , Mario Giuffrida 2, 3 , Fikri Abu-Zidan 4 , Vitor F Kruger 5 , Marco Livrini 1 , Gabriele Luciano Petracca 1 , Giorgio Rossi 1 , Antonio Tarasconi 6 , Brian W C A Tian 7 , Elena Bonati 2 , Ricardo Mentz 8 , Federico N Mazzini 8 , Juan P Campana 8 , Elisabeth Gasser 9 , Reinhold Kafka-Ritsch 9 , Daniel M Felsenreich 10 , Christopher Dawoud 10 , Stefan Riss 10 , Carlos Augusto Gomes 11 , Felipe Couto Gomes 11 , Ricardo Alessandro Teixeira Gonzaga 12 , Cassio Alfred Brattig Canton 12 , Bruno Monteiro Pereira 13 , Gustavo P Fraga 5 , Leticia Gonçalves Zem 5 , Vinicius Cordeiro-Fonseca 14 , Renato de Mesquita Tauil 14 , Boyko Atanasov 15 , Nikolay Belev 15 , Nikola Kovachev 15 , L Juan José Meléndez 16 , Ana Dimova 17 , Stefan Dimov 17 , Zdravko Zelić 17 , Goran Augustin 18 , Branko Bogdanić 18 , Trpimir Morić 18 , Elie Chouillard 19 , Melinda Bajul 20 , Belinda De Simone 21 , Yves Panis 22 , Francesco Esposito 23 , Margherita Notarnicola 24, 25 , Lelde Lauka 24 , Anna Fabbri 24 , Hassen Hentati 25 , Iskander Fnaiech 25 , Venara Aurélien 26 , Marie Bougard 26 , Maxime Roulet 26 , Zaza Demetrashvili 27 , Irakli Pipia 27 , Giorgi Merabishvili 27 , Konstantinos Bouliaris 28 , Georgios Koukoulis 28 , Christos Doudakmanis 28 , Sofia Xenaki 29 , Emmanuel Chrysos 29 , Stamatios Kokkinakis 29 , Panteleimon Vassiliu 30 , Nikolaos Michalopoulos 30 , Ioannis Margaris 30 , Aristotelis Kechagias 31 , Konstantinos Avgerinos 31 , Jevgeni Katunin 31 , Eftychios Lostoridis 32 , Eleni-Aikaterini Nagorni 32 , Antonio Pujante 32 , Francesk Mulita 33 , Ioannis Maroulis 33 , Michail Vailas 33 , Athanasios Marinis 34 , Ioannis Siannis 34 , Eirini Bourbouteli 34 , Dimitrios K Manatakis 35 , Nikolaos Tasis 35 , Vasileios Acheimastos 35 , Sotiropoulou Maria 36 , Kapiris Stylianos 36 , Harilaos Kuzeridis 36 , Dimitrios Korkolis 37 , Evangelos Fradelos 37 , George Kavalieratos 37 , Thalia Petropoulou 38 , Andreas Polydorou 38 , Ioannis Papacostantinou 38 , Tania Triantafyllou 39 , Despina Kimpizi 39 , Dimitrios Theodorou 39 , Konstantinos Toutouzas 40 , Alexandros Chamzin 40 , Maximos Frountzas 40 , Dimitrios Schizas 41 , Ioannis Karavokyros 41 , Athanasios Syllaios 41 , Alexandros Charalabopoulos 42 , Maria Boura 42 , Efstratia Baili 42 , Orestis Ioannidis 43 , Lydia Loutzidou 43 , Elissavet Anestiadou 43 , Ioannis Tsouknidas 44 , Georgios Petrakis 44 , Eleni Polenta 44 , Lovenish Bains 45 , Rahul Gupta 46 , Sudhir K Singh 46 , Archana Khanduri 46 , Miklosh Bala 47 , Asaf Kedar 47 , Marcello Pisano 48 , Mauro Podda 48 , Adolfo Pisanu 48 , Gennaro Martines 49 , Giuseppe Trigiante 49 , Giuliano Lantone 49 , Antonino Agrusa 50 , Giuseppe Di Buono 50 , Salvatore Buscemi 50 , Massimiliano Veroux 51 , Rossella Gioco 51 , Gastone Veroux 51 , Luigi Oragano 52 , Sandro Zonta 52 , Federico Lovisetto 52 , Carlo V Feo 53 , Antonio Pesce 53 , Nicolò Fabbri 53 , Giulio Lantone 54 , Fabio Marino 54 , Fabrizio Perrone 54 , Leonardo Vincenti 55 , Vincenzo Papagni 55 , Arcangelo Picciariello 55 , Stefano Rossi 56 , Biagio Picardi 56 , Simone Rossi Del Monte 56 , Diego Visconti 57 , Giulia Osella 57 , Luca Petruzzelli 57 , Giusto Pignata 58 , Jacopo Andreuccetti 58 , Rossella D'Alessio 58 , Massimo Buonfantino 59 , Eleonora Guaitoli 59 , Stefano Spinelli 59 , Gianluca Matteo Sampietro 60 , Carlo Corbellini 60 , Leonardo Lorusso 60 , Alice Frontali 61, 62 , Isabella Pezzoli 61 , Alessandro Bonomi 61 , Andrea Chierici 62 , Christian Cotsoglou 62 , Giuseppe Manca 63 , Antonella Delvecchio 63 , Nicola Musa 63 , Massimiliano Casati 64 , Laface Letizia 64 , Emmanuele Abate 64 , Giorgio Ercolani 65 , Fabrizio D'Acapito 65 , Leonardo Solaini 65 , Gianluca Guercioni 66 , Simone Cicconi 66 , Diego Sasia 67 , Felice Borghi 67 , Giorgio Giraudo 67 , Giuseppe Sena 68 , Pasquale Castaldo 68 , Eugenia Cardamone 68 , Giuseppe Portale 69 , Matteo Zuin 69 , Ylenia Spolverato 69 , Marialusia Esposito 70 , Roberta Maria Isernia 70 , Maria Di Salvo 70 , Romina Manunza 71 , Giuseppe Esposito 71 , Marcello Agus 71 , Emanuele Luigi Giuseppe Asti 72 , Daniele Tiziano Bernardi 72 , Tommaso Panici Tonucci 72 , Davide Luppi 73 , Massimiliano Casadei 73 , Stefano Bonilauri 73 , Angela Pezzolla 74 , Annunziata Panebianco 74 , Rita Laforgia 74 , Maurizio De Luca 75 , Monica Zese 75 , Dario Parini 75 , Elio Jovine 76 , Giuseppina De Sario 76 , Raffaele Lombardi 76 , Giovanni Aprea 77 , Giuseppe Palomba 77 , Marianna Capuano 77 , Giulio Argenio 78 , Gianluca Orio 78 , Mariano Fortunato Armellino 78 , Marina Troian 79 , Martina Guerra 79 , Carlo Nagliati 79 , Alan Biloslavo 80 , Paola Germani 80 , Giada Aizza 80 , Igor Monsellato 81 , Ali Chaouki Chahrour 81 , Gabriele Anania 82 , Cristina Bombardini 82 , Francesco Bagolini 82 , Gabriele Sganga 83 , Pietro Fransvea 83 , Valentina Bianchi 83 , Paolo Boati 84 , Francesco Ferrara 84 , Francesco Palmieri 84 , Pasquale Cianci 85 , Domenico Gattulli 85 , Enrico Restini 85 , Nicola Cillara 86 , Alessandro Cannavera 86 , Gabriela Elisa Nita 87 , Jlenia Sarnari 87 , Francesco Roscio 88 , Federico Clerici 88 , Ildo Scandroglio 88 , Stefano Berti 89 , Alessandro Cadeo 89 , Alice Filippelli 89 , Luigi Conti 90 , Carmine Grassi 90 , Gaetano Maria Cattaneo 90 , Marina Pighin 91 , Davide Papis 91 , Giovanni Gambino 92 , Vanessa Bertino 92 , Domenico Schifano 92 , Daniela Prando 93 , Luisella Fogato 93 , Fabio Cavallo 93 , Luca Ansaloni 94 , Roberto Picheo 94 , Nicholas Pontarolo 94 , Norma Depalma 95 , Marcello Spampinato 95 , Stefano D'Ugo 95 , Luca Lepre 96 , Michela Giulii Capponi 96 , Rossella Domenica Campa 96 , Giuliano Sarro 97, 98 , Vincenza Paola Dinuzzi 97 , Stefano Olmi 99 , Matteo Uccelli 99 , Davide Ferrari 99 , Marco Inama 100 , Gianluigi Moretto 100 , Michele Fontana 100 , Francesco Favi 101 , Erika Picariello 101 , Alessia Rampini 101 , Andrea Barberis 102 , Antonio Azzinnaro 102 , Alba Oliva 102 , Luigi Totaro 103 , Ilaria Benzoni 103 , Valerio Ranieri 103 , Gabriella Teresa Capolupo 104 , Filippo Carannante 104 , Marco Caricato 104 , Maurizio Ronconi 105 , Silvia Casiraghi 105 , Giovanni Casole 105 , Desire Pantalone 106 , Giovanni Alemanno 106 , Maximilian Scheiterle 106 , Marco Ceresoli 107 , Marco Cereda 107 , Chiara Fumagalli 107 , Federico Zanzi 108 , Stefano Bolzon 108 , Enrico Guerra 108 , Francesca Lecchi 109 , Paola Cellerino 109 , Antonella Ardito 109 , Rosa Scaramuzzo 110 , Andrea Balla 110 , Pasquale Lepiane 110 , Nicola Tartaglia 111 , Antonio Ambrosi 111 , Giovanna Pavone 111 , Gian Marco Palini 112 , Simone Veneroni 112 , Gianluca Garulli 112 , Claudio Ricci 113, 114 , Beatrice Torre 113, 114 , Iris Shari Russo 113, 114 , Matteo Rottoli 113, 114 , Marta Tanzanu 113, 114 , Angela Belvedere 113, 114 , Marco Milone 115 , Michele Manigrasso 115 , Giovanni Domenico De Palma 115 , Micaela Piccoli 116 , Gianmaria Casoni Pattacini 116 , Stefano Magnone 117 , Paolo Bertoli 117 , Michele Pisano 117 , Paolo Massucco 118 , Marco Palisi 118 , Andrea-Pierre Luzzi 118 , Francesco Fleres 119 , Guglielmo Clarizia 119 , Alessandro Spolini 119 , Yoshiro Kobe 120 , Takayuki Toma 120 , Fumihiko Shimamura 120 , Robert Parker 121 , Sinkeet Ranketi 121 , Mercy Mitei 121 , Saulius Svagzdys 122 , Henrikas Pauzas 122 , Justas Zilinskas 122 , Tomas Poskus 123 , Marius Kryzauskas 123 , Matas Jakubauskas 123 , Andee Dzulkarnaen Zakaria 124 , Zaidi Zakaria 124 , Michael Pak-Kai Wong 124 , Asri Che Jusoh 125 , Muhammad Nazreen Zakaria 125 , Daniel Rios Cruz 126 , Aurea Barbara Rodriguez Elizalde 126 , Alejandro Bañon Reynaud 126 , Edgard Efren Lozada Hernandez 127 , Jose Maria Victor Palomo Monroy 127 , Diego Hinojosa-Ugarte 127 , Martha Quiodettis 128 , María Esther Du Bois 128 , José Latorraca 128 , Piotr Major 129 , Michał Pędziwiatr 129 , Magdalena Pisarska-Adamczyk 129 , Maciej Walędziak 130 , Andrzej Kwiatkowski 130 , Łukasz Czyżykowski 130 , Silvia Dantas da Costa 131 , Bela Pereira 131 , Ana Rita Oliveira Ferreira 131 , Filipe Almeida 132 , Ricardo Rocha 132 , Carla Carneiro 132 , Diego Pita Perez 133 , João Carvas 133 , Catarina Rocha 133 , Cátia Ferreira 134 , Rita Marques 134 , Urânia Fernandes 134 , Pedro Leao 135 , André Goulart 135 , Rita Gonçalves Pereira 136 , Sara Daniela Direito Patrocínio 136 , Nuno Gonçalo Gonçalves de Mendonça 136 , Maria Isabel Cerqueira Manso 137 , Henrique Manuel Cardoso Morais 137 , Paulo Sebastião Cardoso 137 , Valentin Calu 138 , Adrian Miron 138 , Elena Adelina Toma 138 , Mahir Gachabayov 139 , Abakar Abdullaev 139 , Andrey Litvin 140 , Taras Nechay 141 , Alexander Tyagunov 141 , Anvar Yuldashev 141 , Alison Bradley 142 , Michael Wilson 142 , Arpád Panyko 143 , Zuzana Látečková 143 , Vladimír Lacko 143 , Dusan Lesko 144 , Marek Soltes 144 , Jozef Radonak 144 , Victor Turrado-Rodriguez 145 , Roser Termes-Serra 145 , Xavier Morales-Sevillano 145 , Pierfrancesco Lapolla 146 , Andrea Mingoli 146 , Gioia Brachini 146 , Maurizio Degiuli 147 , Silvia Sofia 147 , Rossella Reddavid 147 , Andrea de Manzoni Garberini 148 , Angelica Buffone 148 , Eduardo Perea Del Pozo 149 , Daniel Aparicio-Sánchez 149 , Sandra Dos Barbeito 149 , Mercedes Estaire-Gómez 150 , Rebeca Vitón-Herrero 150 , Mª de Los Ángeles Gil Olarte-Marquez 150 , José Gil-Martínez 151 , Felipe Alconchel 151 , Tatiana Nicolás-López 151 , Aida Cristina Rahy-Martin 152 , María Pelloni 152 , Raquel Bañolas-Suarez 152 , Fernando Mendoza-Moreno 153 , Francisca García-Moreno Nisa 153 , Manuel Díez-Alonso 153 , María Elisa Valle Rodas 154 , María Carmona Agundez 154 , María Inmaculada Pérez Andrés 154 , Claudia Cristina Lopes Moreira 155 , Aintzane Lizarazu Perez 155 , Iñigo Augusto Ponce 155 , Ana María González-Castillo 156 , Estela Membrilla-Fernández 156 , Silvia Salvans 156 , Mario Serradilla-Martín 157 , Pablo Sancho Pardo 157 , Daniel Rivera-Alonso 158 , Jana Dziakova 158 , Jose Mugüerza Huguet 158 , Naila Pagès Valle 159 , Enrique Colás Ruiz 159 , Cristina Rey Valcárcel 160 , Cristina Ruiz Moreno 160 , Yeniffer Tatiana Moreno Salazar 160 , Juan Jesús Rubio García 161 , Silvia Sevila Micó 161 , Joaquín Ruiz López 161 , Silvia Pérez Farré 162 , Maite Santamaria Gomez 162 , Nuria Mestres Petit 162 , Alberto Titos-García 163 , Jose Manuel Aranda-Narváez 163 , Laura Romacho-López 163 , Luis Sánchez-Guillén 164 , Veronica Aranaz-Ostariz 164 , Marina Bosch-Ramírez 164 , Aleix Martínez-Pérez 165 , Elías Martínez-López 165 , Juan Carlos Sebastián-Tomás 165 , Granada Jimenez-Riera 166 , Javier Jimenez-Vega 166 , Jose Aurelio Navas Cuellar 166 , Andrea Campos-Serra 167 , Anna Muñoz-Campaña 167 , Raquel Gràcia-Roman 167 , Javier Martínez Alegre 168 , Francisca Lima Pinto 168 , Sara Nuñez O'Sullivan 168 , Francisco Blanco Antona 169 , Beatriz Muñoz Jiménez 169 , Jaime López-Sánchez 169 , Zahira Gómez Carmona 170 , Rocio Torres Fernández 170 , Isabel Blesa Sierra 170 , Laura Román García de León 171 , Verónica Polaino Moreno 171 , Eva Iglesias 171 , Paola Lora Cumplido 172 , Altea Arango Bravo 172 , Ignacio Rey Simó 173 , Carlota López Domínguez 173 , Aloia Guerreiro Caamaño 173 , Rafael Calleja Lozano 174 , Manuel Durán Martínez 174 , Álvaro Naranjo Torres 174 , Javier Tomas Morales Bernaldo de Quiros 175 , Gianluca Pellino 176 , Miriam Moratal Cloquell 176 , Elsa García Moller 176 , Sami Jalal-Eldin 177 , Ahmed K Abdoun 177 , Hytham K S Hamid 177 , Varut Lohsiriwat 178 , Aitsariya Mongkhonsupphawan 178 , Oussama Baraket 179 , Karim Ayed 179 , Imed Abbassi 179 , Ali Ben Ali 180 , Houssem Ammar 180 , Ali Kchaou 181 , Ahmed Tlili 181 , Imen Zribi 181 , Elif Colak 182 , Suleyman Polat 182 , Zehra Alan Koylu 182 , Ali Guner 183 , Mehmet Arif Usta 183 , Murat Emre Reis 183 , Baris Mantoglu 184 , Emre Gonullu 184 , Emrah Akin 185 , Fatih Altintoprak 185 , Zulfu Bayhan 185 , Necattin Firat 185 , Arda Isik 186 , Ufuk Memis 186 , Mehmet Bayrak 187 , Yasemin Altıntaş 187 , Yasin Kara 188 , Mehmet Abdussamet Bozkurt 188 , Ali Kocataş 188 , Koray Das 189 , Ahmet Seker 189 , Nazmi Ozer 189 , Semra Demirli Atici 190 , Korhan Tuncer 190 , Tayfun Kaya 190 , Zeynep Ozkan 191 , Onur Ilhan 191 , Ibrahim Agackiran 191 , Mustafa Yener Uzunoglu 192 , Eren Demirbas 192 , Yuksel Altinel 193 , Serhat Meric 193 , Nadir Adnan Hacım 193 , Derya Salim Uymaz 194 , Nail Omarov 194 , Emre Balık 194 , Giovanni D Tebala 195 , Hany Khalil 195 , Mridul Rana 195 , Mansoor Khan 196 , Charlotte Florence 196 , Christie Swaminathan 196 , Cosimo Alex Leo 197 , Lampros Liasis 197 , Josef Watfah 197 , Ivan Trostchansky 198 , Edward Delgado 198 , Marcelo Pontillo 198 , Rifat Latifi 199 , Raul Coimbra 200 , Sara Edwards 200 , Ana Lopez 200 , George Velmahos 201 , Ander Dorken 201 , Anthony Gebran 201 , Amanda Palmer 202 , Jeffrey Oury 202 , James M Bardes 202 , Sirivan Suon Seng 203 , Lauren S Coffua 203 , Asanthi Ratnasekera 203 , Tanya Egodage 204 , Karla Echeverria-Rosario 204 , Isabella Armento 204 , Lena M Napolitano 205 , Naveen F Sangji 205 , Mark Hemmila 205 , Jacob A Quick 206 , Tyler R Austin 206 , Theodore S Hyman 206 , William Curtiss 207 , Amanda McClure 207 , Nicholas Cairl 207 , Walter L Biffl 208 , Hung P Truong 208 , Kathryn Schaffer 208 , Summer Reames 208 , Filippo Banchini 3 , Patrizio Capelli 3 , Federico Coccolini 209 , Massimo Sartelli 210 , Francesca Bravi 211 , Carlo Vallicelli 101 , Vanni Agnoletti 101 , Gian Luca Baiocchi 212 , Fausto Catena 101
Affiliation  

Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. After 100 years since the first Hartmann’s procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment’s choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.

中文翻译:


再见哈特曼试验:一项针对一个世纪前开发的外科手术当前使用情况的前瞻性、国际、多中心、观察性研究



文献建议用结肠切除加一期吻合术(RPA)代替哈特曼手术(HP)来治疗左侧结肠急症。我们的目的是比较 HP 和 RPA,评估全球用于治疗急性左侧结肠急症患者的手术选择以及导致选择治疗的因素。这是一项在 ClinicalTrials.gov 上注册的前瞻性、国际、多中心观察性研究。 2020年3月1日至2020年5月31日期间,共纳入来自204个中心的1215名需要手术的左侧结肠急症患者,并进行了为期1年的随访。 564 名患者(43.1%)为女性。平均年龄为 65.9 ± 15.6 岁。 697 例 (57.3%) 患者进行了 HP,384 例 (31.6%) 患者进行了 RPA。复杂性急性憩室炎是左侧结肠急症的最常见原因(40.2%),其次是结直肠恶性肿瘤(36.6%)。 HP 组的严重并发症 (Clavien-Dindo ≥ 3b) 较高 (P < 0.001)。 HP 患者的 30 天死亡率较高(13.7%),特别是在肠穿孔和弥漫性腹膜炎的情况下。 1 年随访显示 HP 和 RPA 的造口复通率没有差异。 (P = 0.127)。后向似然 Logistic 回归模型显示,对于年轻患者、ASA 评分较低(≤ 3)、大肠梗阻、无结肠缺血、从入院到手术时间较长、在白天工作时间较早进行手术的患者,RPA 是首选,由一位进行了 50 多次结直肠切除术的外科医生完成。自第一次哈特曼手术以来 100 年后,HP 仍然是左侧结直肠急症最常见的治疗方法。 治疗方法的选择取决于患者特征、手术时间和外科医生的经验。 RPA 应被视为手术的黄金标准,HP 是一个例外。
更新日期:2024-04-16
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