Trillions of intestinal bacteria in the human body undergo dynamic transformations in response to physiological and pathological changes. Alterations in their composition and metabolites collectively contribute to the progression of Alzheimer’s disease. The role of gut microbiota in Alzheimer’s disease is diverse and complex, evidence suggests lipid metabolism may be one of the potential pathways. However, the mechanisms that gut microbiota mediate lipid metabolism in Alzheimer’s disease pathology remain unclear, necessitating further investigation for clarification. This review highlights the current understanding of how gut microbiota disrupts lipid metabolism and discusses the implications of these discoveries in guiding strategies for the prevention or treatment of Alzheimer’s disease based on existing data.

中文翻译：

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阿尔茨海默氏病中肠道微生物群-宿主脂质串扰：对疾病进展和治疗的影响

人体内数以万亿计的肠道细菌因生理和病理变化而发生动态变化。它们的组成和代谢物的改变共同导致阿尔茨海默病的进展。肠道微生物群在阿尔茨海默病中的作用是多样且复杂的，有证据表明脂质代谢可能是潜在的途径之一。然而，肠道微生物群在阿尔茨海默病病理学中介导脂质代谢的机制仍不清楚，需要进一步研究以澄清。这篇综述强调了目前对肠道微生物群如何破坏脂质代谢的理解，并讨论了这些发现对基于现有数据指导预防或治疗阿尔茨海默病策略的影响。