MucR belongs to a large protein family whose members regulate the expression of virulence and symbiosis genes in α‐proteobacteria species. This protein and its homologs were initially studied as classical transcriptional regulators mostly involved in repression of target genes by binding their promoters. Very recent studies have led to the classification of MucR as a new type of Histone‐like Nucleoid Structuring (H‐NS) protein. Thus this review is an effort to put together a complete and unifying story demonstrating how genetic and biochemical findings on MucR suggested that this protein is not a classical transcriptional regulator, but functions as a novel type of H‐NS‐like protein, which binds AT‐rich regions of genomic DNA and regulates gene expression.

中文翻译：

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MucR 蛋白：三十年的研究鉴定出一种新的 H-NS 样蛋白

MucR 属于一个大蛋白家族，其成员调节 α-变形菌物种中毒力和共生基因的表达。这种蛋白质及其同源物最初被研究为经典转录调节因子，主要通过结合靶基因的启动子来抑制靶基因。最近的研究将 MucR 分类为一种新型组蛋白样核结构 (H-NS) 蛋白。因此，这篇综述旨在整理出一个完整且统一的故事，展示 MucR 的遗传和生化发现如何表明该蛋白不是经典的转录调节因子，而是作为一种新型 H-NS 样蛋白发挥作用，该蛋白结合 AT ‐丰富的基因组 DNA 区域并调节基因表达。