Study design

Scoping systematic review.

Objectives

To summarize the available experimental clinical and animal studies for the identification of all CSF and serum-derived biochemical markers in human and rat SCI models.

Setting

Tehran, Iran.

Methods

In this scoping article, we systematically reviewed the electronic databases of PubMed, Scopus, WOS, and CENTRAL to retrieve current literature assessing the levels of different biomarkers in human and rat SCI models.

Results

A total of 19,589 articles were retrieved and 6897 duplicated titles were removed. The remaining 12,692 studies were screened by their title/abstract and 12,636 were removed. The remaining 56 were considered for full-text assessment, and 11 papers did not meet the criteria, and finally, 45 studies were included. 26 studies were human observational studies comprising 1630 patients, and 19 articles studied SCI models in rats, including 832 rats. Upon reviewing the literature, we encountered a remarkable heterogeneity in terms of selected biomarkers, timing, and method of measurement, studied models, extent, and mechanism of injury as well as outcome assessment measures.

Conclusions

The specific expression and distribution patterns of biomarkers in relation to spinal cord injury (SCI) phases, and their varied concentrations over time, suggest that cerebrospinal fluid (CSF) and blood biomarkers are effective measures for assessing the severity of SCI.

中文翻译：

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人和大鼠的急性脊髓损伤血清生物标志物：范围系统评价

学习规划

范围系统审查。

目标

总结现有的实验临床和动物研究，用于鉴定人和大鼠 SCI 模型中所有脑脊液和血清衍生的生化标志物。

环境

伊朗德黑兰。

方法

在这篇范围界定文章中，我们系统地回顾了 PubMed、Scopus、WOS 和 CENTRAL 的电子数据库，以检索当前评估人类和大鼠 SCI 模型中不同生物标志物水平的文献。

结果

共检索文章19589篇，删除重复标题6897篇。其余 12,692 项研究按标题/摘要进行筛选，其中 12,636 项被删除。其余56篇论文考虑进行全文评估，11篇论文不符合标准，最终纳入45篇研究。 26 项研究是人类观察性研究，涉及 1630 名患者，19 篇文章研究大鼠 SCI 模型，其中包括 832 只大鼠。在回顾文献后，我们发现在选定的生物标志物、时间和测量方法、研究模型、损伤程度和机制以及结果评估措施方面存在显着的异质性。

结论

与脊髓损伤 (SCI) 阶段相关的生物标志物的具体表达和分布模式及其随时间变化的浓度表明，脑脊液 (CSF) 和血液生物标志物是评估 SCI 严重程度的有效措施。