On the Mechanisms of Hypohalous Acid Formation and Electrophilic Halogenation by Non-Native Halogenases,Angewandte Chemie International Edition

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On the Mechanisms of Hypohalous Acid Formation and Electrophilic Halogenation by Non-Native Halogenases
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-04-12 , DOI: 10.1002/anie.202403858
Kridsadakorn Prakinee ₁ , Narin Lawan ₂ , Aisaraphon Phintha ₁ , Surawit Visitsatthawong ₁ , Penchit Chitnumsub _{1,

3} , Watcharapa Jitkaroon ₁ , Pimchai Chaiyen ₁

Affiliation

Electrophilic halogenases in nature are typically not efficient. Guided by flavin-dependent halogenase mechanisms and taking advantage of the versatile reactivity of a flavin hydroperoxide adduct and in situ generation of H₂O₂ by flavin-dependent enzymes, it was possible to promote the formation of a hypohalous acid—which is key for electrophilic halogenation—in various non-native halogenases by rerouting the flavin-generated peroxide.

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