Cross-selective Deoxygenative Coupling of Aliphatic Alcohols: Installation of Methyl Groups including Isotopic Labels by Nickel Catalysis,Angewandte Chemie International Edition

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Cross-selective Deoxygenative Coupling of Aliphatic Alcohols: Installation of Methyl Groups including Isotopic Labels by Nickel Catalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-04-11 , DOI: 10.1002/anie.202403119
Patricia C Lin ₁ , Chloe D Wong ₁ , Elizabeth R Jarvo ₁

Affiliation

This nickel-catalyzed cross-electrophile coupling reaction provides, for the first time, a cross-selective reaction of two alcohols. Methanol, activated as methyl tosylate, undergoes XEC with a range of secondary alcohols activated as the corresponding mesylates. Catalyst turnover is achieved with a stoichiometric reducing metal or electrochemically. This transformation provides facile incorporation of isotopic labels, by deuteration of ketone intermediates and/or employing isotopically labelled methanol.

中文翻译：

脂肪醇的交叉选择性脱氧偶联：通过镍催化安装甲基（包括同位素标记）

这种镍催化的交叉亲电子偶联反应首次提供了两种醇的交叉选择性反应。活化为甲苯磺酸甲酯的甲醇与一系列活化为相应甲磺酸酯的仲醇进行 XEC。催化剂周转是通过化学计量还原金属或电化学方法实现的。通过酮中间体的氘化和/或使用同位素标记的甲醇，这种转化提供了同位素标记的轻松掺入。

更新日期：2024-04-11

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