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Mood variability during adolescent development and its relation to sleep and brain development
Scientific Reports ( IF 3.8 ) Pub Date : 2024-04-12 , DOI: 10.1038/s41598-024-59227-9
Yara J Toenders 1, 2, 3 , Renske van der Cruijsen 3 , Jana Runze 4 , Suzanne van de Groep 3 , Lara Wierenga 1, 2 , Eveline A Crone 1, 2, 3
Affiliation  

Mood swings, or mood variability, are associated with negative mental health outcomes. Since adolescence is a time when mood disorder onset peaks, mood variability during this time is of significant interest. Understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety disorders. Data from the longitudinal Leiden self-concept study (N = 191) over 5 yearly timepoints was used to study the association between sleep, brain structure, and mood variability in healthy adolescents aged 11–21 at baseline in this pre-registered study. Sleep was measured both objectively, using actigraphy, as well as subjectively, using a daily diary self-report. Negative mood variability was defined as day-to-day negative mood swings over a period of 5 days after an MRI scan. It was found that negative mood variability peaked in mid-adolescence in females while it linearly increased in males, and average negative mood showed a similar pattern. Sleep duration (subjective and objective) generally decreased throughout adolescence, with a larger decrease in males. Mood variability was not associated with sleep, but average negative mood was associated with lower self-reported energy. In addition, higher thickness in the dorsolateral prefrontal cortex (dlPFC) compared to same-age peers, suggesting a delayed thinning process, was associated with higher negative mood variability in early and mid-adolescence. Together, this study provides an insight into the development of mood variability and its association with brain structure.



中文翻译:


青少年发育期间的情绪变化及其与睡眠和大脑发育的关系



情绪波动或情绪变化与负面的心理健康结果相关。由于青春期是情绪障碍发病高峰的时期,因此这段时期的情绪变化引起了人们的极大关注。了解可能与情绪变异相关的生物因素,例如睡眠和大脑结构发育,可以阐明情绪和焦虑症的潜在机制。在这项预先注册的研究中,使用来自莱顿自我概念纵向研究(N = 191)超过 5 年时间点的数据来研究 11-21 岁健康青少年基线时的睡眠、大脑结构和情绪变异之间的关联。睡眠测量既通过体动记录仪进行客观测量,又通过每日日记自我报告进行主观测量。负面情绪波动被定义为 MRI 扫描后 5 天内每天的负面情绪波动。研究发现,女性的负面情绪波动在青春期中期达到顶峰,而男性则呈线性增加,平均负面情绪也呈现出类似的模式。整个青春期的睡眠时间(主观和客观)普遍减少,其中男性减少幅度更大。情绪波动与睡眠无关,但平均负面情绪与自我报告的精力较低有关。此外,与同龄人相比,背外侧前额叶皮层(dlPFC)厚度较高,表明变薄过程延迟,与青春期早期和中期较高的负面情绪变异性相关。总之,这项研究提供了对情绪变异的发展及其与大脑结构的关联的深入了解。

更新日期:2024-04-12
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