The purpose of this study is to verify the effect of anisotropic property of retinal biomechanics on vasodilation measurement. A custom-built optical coherence tomography (OCT) was used for time-lapse imaging of flicker stimulation-evoked vessel lumen changes in mouse retinas. A comparative analysis revealed significantly larger (18.21%) lumen dilation in the axial direction compared to the lateral (10.77%) direction. The axial lumen dilation predominantly resulted from the top vessel wall movement toward the vitreous direction, whereas the bottom vessel wall remained stable. This observation indicates that the traditional vasodilation measurement in the lateral direction may result in an underestimated value.

中文翻译：

---

功能性 OCT 揭示视网膜闪烁引起的血管舒张的各向异性变化

本研究的目的是验证视网膜生物力学的各向异性特性对血管舒张测量的影响。使用定制的光学相干断层扫描（OCT）对闪烁刺激引起的小鼠视网膜血管腔变化进行延时成像。比较分析显示，轴向管腔扩张 (18.21%) 明显大于横向管腔扩张 (10.77%)。轴向管腔扩张主要是由于顶部血管壁向玻璃体方向移动，而底部血管壁保持稳定。这一观察结果表明，传统的横向血管舒张测量可能会导致低估值。