Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis,Drug Resistance Updates

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Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2024-03-29 , DOI: 10.1016/j.drup.2024.101083
Qi Wang ₁ , Ruobing Wang ₁ , Shuyi Wang ₁ , Anru Zhang ₁ , Qiaoyan Duan ₁ , Shijun Sun ₁ , Longyang Jin ₂ , Xiaojuan Wang ₁ , Yawei Zhang ₁ , Chunlei Wang ₂ , Haiquan Kang ₃ , Zhijie Zhang ₄ , Kang Liao ₅ , Yinghui Guo ₆ , Liang Jin ₇ , Zhiwu Liu ₈ , Chunxia Yang ₉ , Hui Wang ₁ ,

Affiliation

Carbapenem-resistant (CRKP) is a global threat that varies by region. The global distribution, evolution, and clinical implications of the ST11 CRKP clone remain obscure. We conducted a multicenter molecular epidemiological survey using isolates obtained from 28 provinces and municipalities across China between 2011 and 2021. We integrated sequences from public databases and performed genetic epidemiology analysis of ST11 CRKP. Among ST11 CRKP, KL64 serotypes exhibited considerable expansion, increasing from 1.54% to 46.08% between 2011 and 2021. Combining our data with public databases, the phylogenetic and phylogeography analyses indicated that ST11 CRKP appeared in the Americas in 1996 and spread worldwide, with key clones progressing from China’s southeastern coast to the inland by 2010. Global phylogenetic analysis showed that ST11 KL64 CRKP has evolved to a virulent, resistant clade with notable regional spread. Single-nucleotide polymorphism (SNP) analysis identified BMPPS ( and ) as a key marker for this clade. The BMPPS SNP clade is associated with high mortality and has strong anti-phagocytic and competitive traits . The high-risk ST11 KL64 CRKP subclone showed strong expansion potential and survival advantages, probably owing to genetic factors.

更新日期：2024-03-29

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