Up to 50% of individuals develop post-traumatic osteoarthritis (PTOA) within 10 years following knee-joint injuries such as anterior cruciate ligament rupture or acute meniscal tear. Lower-extremity PTOA prevalence is estimated to account for ≥12% of all symptomatic osteoarthritis (OA), or approximately 5.6 million cases in the USA. With knowledge of the inciting event, it might be possible to ‘catch PTOA in the act’ with sensitive imaging and soluble biomarkers and thereby prevent OA sequelae by early intervention. Existing biomarker data in the joint-injury literature can provide insights into the pathogenesis and early risk trajectory related to PTOA and can help to elucidate a research agenda for preventing or slowing the onset of PTOA. Non-traumatic OA and PTOA have many clinical, radiological and genetic similarities, and efforts to understand early risk trajectories in PTOA might therefore contribute to the identification and classification of early non-traumatic OA, which is the most prevalent form of OA.

多达 50% 的人在前十字韧带断裂或急性半月板撕裂等膝关节损伤后 10 年内出现创伤后骨关节炎 (PTOA)。据估计，下肢 PTOA 患病率占所有有症状骨关节炎 (OA) 的 12% 以上，即美国大约有 560 万例。有了对诱发事件的了解，就有可能通过灵敏的成像和可溶性生物标志物“及时发现 PTOA”，从而通过早期干预来预防 OA 后遗症。关节损伤文献中现有的生物标志物数据可以深入了解与 PTOA 相关的发病机制和早期风险轨迹，并有助于阐明预防或减缓 PTOA 发病的研究议程。非创伤性 OA 和 PTOA 有许多临床、放射学和遗传相似性，因此了解 PTOA 早期风险轨迹的努力可能有助于早期非创伤性 OA（最常见的 OA 形式）的识别和分类。