Classic Hodgkin lymphoma (CHL) can arise in patients with low-grade B-cell lymphoma. The features of CHL arising in follicular lymphoma (FL) and its outcome are still unclear, mainly due to the very few cases reported. This study compares 17 patients with CHL and FL to 2 control groups: 1 of 26 patients with FL and a second of 60 patients older than 40 when diagnosed with CHL. Of the FL and CHL patients, 8 had simultaneous FL and CHL, while 9 had FL first, followed by CHL 4.7 years later on average. The age at the diagnosis of FL was 61 years for patients with synchronous FL and CHL and of 60 years for FL, followed by CHL at 65 years. Patients with FL only were, on average, 59 years old at presentation, while CHL patients were 61. FL was grade 1-2 in 75% of FL and CHL patients and 67% of FL first and CHL second patients, lower proportions than in the FL control group-92%. Epstein-Barr virus (EBV) was detected in a lower fraction (29%) of the FL and CHL group than in CHL-only controls (46%). BCL2 translocations were detected in 4 of the 7 cases with FL, but in positive cases, the rearrangement was also present in the CHL component, indicating a clonal relationship between FL and CHL. Patients with FL and CHL treated for CHL had an initial outcome more similar to FL than to CHL controls.

中文翻译：

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与单一恶性肿瘤对照相比，经典霍奇金淋巴瘤和滤泡性淋巴瘤患者。


低度恶性 B 细胞淋巴瘤患者可能出现经典霍奇金淋巴瘤 (CHL)。滤泡性淋巴瘤（FL）引起的 CHL 的特征及其结局仍不清楚，主要是由于报道的病例很少。本研究将 17 名患有 CHL 和 FL 的患者与 2 个对照组进行了比较：其中一组是 26 名患有 FL 的患者，另一组是 60 名年龄超过 40 岁且诊断为 CHL 的患者。在 FL 和 CHL 患者中，8 例同时患有 FL 和 CHL，而 9 例先患有 FL，平均 4.7 年后才患有 CHL。对于同时患有 FL 和 CHL 的患者，诊断 FL 时的年龄为 61 岁；对于 FL，诊断时年龄为 60 岁；随后诊断为 CHL 时年龄为 65 岁。仅患有 FL 的患者就诊时平均年龄为 59 岁，而 CHL 患者为 61 岁。75% 的 FL 和 CHL 患者中 FL 为 1-2 级，首次 FL 和第二次 CHL 患者中这一比例为 67%，比例低于FL对照组-92%。与仅 CHL 对照组 (46%) 相比，FL 和 CHL 组中检测到的 Epstein-Barr 病毒 (EBV) 比例较低 (29%)。 7 例 FL 病例中，有 4 例检测到 BCL2 易位，但在阳性病例中，CHL 成分中也存在重排，表明 FL 和 CHL 之间存在克隆关系。接受 CHL 治疗的 FL 和 CHL 患者的初始结果与 FL 比 CHL 对照更相似。