This study combines the CRISPR/dCas13b and chemical induced proximity (CIP) techniques to develop a small molecule-induced photo-controllable m¹A demethylation editing tool (termed AI-dm¹A) as well as an m¹A methylation editing tool (termed AI-m¹A). These m¹A editing tools are able to regulate the biological function of targeted RNAs by modulating m¹A modifications, which in turn influences cell functions.

中文翻译：

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小分子诱导和光激活细胞 RNA N1-甲基腺苷编辑


本研究结合CRISPR/dCas13b和化学诱导邻近（CIP）技术，开发了小分子诱导光控m ¹ A去甲基化编辑工具（称为AI-dm ¹ A）以及m ¹ A甲基化编辑工具（称为 AI-m ¹ A)。这些 m ¹ A 编辑工具能够通过调节 m ¹ A 修饰来调节目标 RNA 的生物学功能，从而影响细胞功能。