Herein, a highly sensitive, cost-effective, and sustainable electrochemical sensor was developed for the selective sensing of acetaminophen (ACP) in actual samples using cobalt hexacyanoferrate (CHCF) incorporated iron terephthalate metal organic framework (FMF). The CHCF-FMF was sustainably synthesized and characterized using FTIR, XRD and SEM with EDX analysis. Using CHCF-FMF, a modified electrode was fabricated by drop-casting it over a glassy carbon, which on voltammetric investigations, revealed the presence of Co redox couple with a formal potential of 0.51 V. Further, the designed sensor was employed for the electrocatalytic oxidation of ACP, which showed a linear detection range from 0.05 to 7.37 mM with a sensitivity and detection limit of 100.64 µA/mM/cm and 13 µM, respectively. Furthermore, the developed CHCF-FMF/GCE sensing system is highly facile and robust, and it has demonstrated excellent stability, selectivity, repeatability, and good reproducibility. The superior performance was attributed to the formation of CHCF over FMF, which efficiently arranged them to augment the electrochemical and electrocatalytic properties. Besides, the sensor was employed to determine ACP in blood serum, commercial tablets, and environmental samples, which showed recovery ranges of 96.2% – 106.2%. This work provides a novel strategy for designing catalytically active sites at the molecular level, which opens a new avenue in fine-tuning MOFs for their applicability in medical diagnostics, point-of-care, industrial and environmental monitoring devices.

中文翻译：

---

使用六氰基铁酸钴修饰的对苯二甲酸铁金属有机框架对生物流体、药物和环境样品中的对乙酰氨基酚进行电化学传感

在此，开发了一种高灵敏度、经济高效且可持续的电化学传感器，用于使用六氰基铁酸钴（CHCF）结合对苯二甲酸铁金属有机骨架（FMF）选择性检测实际样品中的对乙酰氨基酚（ACP）。 CHCF-FMF 是可持续合成的，并使用 FTIR、XRD 和 SEM 以及 EDX 分析进行表征。使用 CHCF-FMF，通过将其滴铸在玻璃碳上来制造修饰电极，伏安研究表明存在形式电位为 0.51 V 的 Co 氧化还原对。此外，设计的传感器用于电催化ACP 氧化的线性检测范围为 0.05 至 7.37 mM，灵敏度和检测限分别为 100.64 µA/mM/cm 和 13 µM。此外，所开发的CHCF-FMF/GCE传感系统非常简便和稳健，并且表现出优异的稳定性、选择性、重复性和良好的重现性。优异的性能归因于在FMF上形成CHCF，这有效地排列它们以增强电化学和电催化性能。此外，该传感器还用于测定血清、商业片剂和环境样品中的 ACP，回收率范围为 96.2% – 106.2%。这项工作提供了一种在分子水平上设计催化活性位点的新策略，为微调MOFs在医疗诊断、护理点、工业和环境监测设备中的应用开辟了一条新途径。