Skin photoaging is mostly caused by ultraviolet A (UVA), although active medications to effectively counteract UVA-induced photoaging have not yet been created. Resveratrol, a naturally occurring polyphenol found in the skin of grapes, has been shown to have various biological functions such as anti-inflammatory and antioxidant characteristics. However, the role of resveratrol in UVA-induced photoaging has not been clarified. We investigated the mechanism of action of resveratrol by UVA irradiation of human skin fibroblasts (HSF) and innovatively modified a mouse model of photoaging. The results demonstrated that resveratrol promoted AMP-activated protein kinase (AMPK) phosphorylation to activate autophagy, reduce reactive oxygen species (ROS) production, inhibit apoptosis, and restore normal cell cycle to alleviate UVA-induced photoaging. In addition, subcutaneous injection of resveratrol not only improved the symptoms of roughness, erythema, and increased wrinkles in the skin of UVA photodamaged mice, but also alleviated epidermal hyperkeratosis and hyperpigmentation, reduced inflammatory responses, and inhibited collagen fiber degradation. In conclusion, our studies proved that resveratrol can treat UVA-induced photoaging and elucidated the possible molecular mechanisms involved, providing a new therapeutic strategy for future anti-aging.

皮肤光老化主要是由紫外线 A (UVA) 引起的，尽管尚未研制出有效对抗 UVA 引起的光老化的活性药物。白藜芦醇是一种存在于葡萄皮中的天然多酚，已被证明具有多种生物功能，例如抗炎和抗氧化特性。然而，白藜芦醇在 UVA 引起的光老化中的作用尚未明确。我们通过 UVA 照射人皮肤成纤维细胞 (HSF) 来研究白藜芦醇的作用机制，并创新性地修改了光老化小鼠模型。结果表明，白藜芦醇促进 AMP 激活蛋白激酶 (AMPK) 磷酸化，从而激活自噬、减少活性氧 (ROS) 产生、抑制细胞凋亡、恢复正常细胞周期，从而缓解 UVA 引起的光老化。此外，皮下注射白藜芦醇不仅能改善UVA光损伤小鼠皮肤粗糙、红斑、皱纹增多等症状，还能缓解表皮角化过度和色素沉着过度，减轻炎症反应，抑制胶原纤维降解。总之，我们的研究证明白藜芦醇可以治疗UVA引起的光老化，并阐明其可能的分子机制，为未来的抗衰老提供新的治疗策略。